不同胎龄新生儿出生第1天凝血指标的比较研究  

A comparative study on the coagulation indices of newborns of different gestational ages on the first day of birth

作　　者：程光清[1,2] 刘俐[1] 马晓蕾[2] 蔡凯乾[2] 陈群[2] 王安[3] 尚鹏[4] 

机构地区：[1]西安交通大学第一附属医院新生儿科,710061 [2]陕西省安康市中心医院新生儿科 [3]陕西省安康市中心医院产科 [4]陕西省安康市中心医院检验科

出　　处：《中华新生儿科杂志（中英文）》2017年第3期213-216,共4页Chinese Journal of Neonatology

摘　　要：目的 探讨不同胎龄新生儿出生第1天凝血指标的差异.方法 选择2014年1月至2015年12月安康市中心医院出生的早产儿为观察组,根据胎龄分为早期早产儿组、中期早产儿组和晚期早产儿组,按照3：1的比例选择同期出生的健康足月新生儿为对照组（足月儿组）.比较各组新生儿及其母亲临床资料和出生第1天凝血状态.结果 早期早产儿组、中期早产儿组、晚期早产儿组及对照组分别纳入44、50、71、52例.各组早产儿凝血酶原时间（prothrombin time,PT）、活化部分凝血活酶时间（activated partial thromboplastin time,APTT）、凝血酶时间（thrombin time,TT）均长于足月儿组[PI：（16.1±4.3）s、（16.8±4.9）s、（15.8±4.8）s比（13.0±1.3）s,APTT：（88.3±38.1）s、（93.5±37.7）s、（91.0±32.3）s比（66.0±17.8）s,TT：（25.4±4.6）s、（25.1±5.5）s、（25.0±3.3）s比（24.0±3.3）s],纤维蛋白原（fibrinogen,FIB）均低于足月儿组[（1.11 ±0.46） g/L、（1.12±0.44） g/L、（1.12 ±0.45） g/L比（1.28±0.37） g/L],差异有统计学意义（P〈0.05）;3组早产儿比较,各指标差异均无统计学意义（P〉0.05）.各组新生儿母亲各项凝血指标比较,差异均无统计学意义（P〉0.05）.结论 与足月儿相比,早产儿出生第1天凝血功能较差,但不同胎龄早产儿凝血状态无显著差异.Objective To study the differences of coagulation indices on the first day of birth in newborns with different gestational ages.Method Premature infants born in our hospital between January 2014 and December 2015 were enrolled in this study as the observational group,and they were divided into early preterm group,moderate preterm group,and late preterm group according to their gestational ages.Healthy full-term infants born during the same period were selected as the control group by 3：1 The clinicaldata and coagulation indices of the infants and their mothers in each group were compared.Result There were 44,50,71,and 52 cases in the early preterm,moderate preterm,late preterm,and control group,respectively.The prothrombin time （PT）,activated partial thromboplastin time （APTT）,and thrombin time （TT） of the premature infants in the early preterm group,moderate preterm group,and late preterm group were all longer than those of the control group [PT：（16.1 ±4.3） s,（16.8 ±4.9） s,（15.8 ±4.8） s,vs.（13.0±1.3）s;APTT：（88.3±38.1） s,（93.5±37.7） s,（91.0±32.3） s,vs.（66.0±17.8） s;TT：（25.4 ±4.6） s,（25.1 ±5.5） s,（25.0 ±3.3） s,vs.（24.0 ±3.3） s;all P〈0.05].The fibrinogen level of the premature newborns in three groups were all lower than that of the full-term infants in the control group [（1.11 ± 0.46） g/L,（1.12 ± 0.44） g/L,（1.12 ± 0.45） g/L vs.（1.28 ± 0.37） g/L,P 〈 0.05].The differences of all the indices among the three groups of premature infants were all not statistically significant （P 〉 0.05）.The comparison of the coagulation indices of the mothers of the newborns from all four groups showed no significant differences （P 〉 0.05）.Conclusion Compared with full-term infants,preterm infants showed significantly poorer coagulation function on the first day of birth.However,there were no significant differences in coagulation indices among preterm infants of different gestational ages.

关 键 词：凝血酶原时间 凝血酶时间 纤维蛋白原 婴儿 早产 

分 类 号：R722.1[医药卫生—儿科]