环丙沙星致运动神经元病患者心脏骤停及QT间期延长  

Cardiac arrest and prolonged QT interval in a patient with motor neuron disease associated with ciprofloxacin

作　　者：张文娟[1,2] 罗钧沛 胡月琴 

机构地区：[1]遵义医学院第五附属(珠海)医院药学部,广东珠海519100 [2]湖北宜昌市中心人民医院/三峡大学第一临床医学院药学部,443003

出　　处：《药物不良反应杂志》2017年第5期378-379,共2页Adverse Drug Reactions Journal

摘　　要：1例70岁女性运动神经元病患者因慢性支气管炎急性发作予环丙沙星0.4 g静脉滴注,1次/d.第10天,患者出现低钾血症,血钾2.7 mmol/L,给予补钾治疗;第11天,患者突发意识丧失、心脏骤停,立即予胸外按压,约3 min后患者神志转清,心电监护示尖端扭转型室性心动过速,按心率校正的QT（QTc）间期为546 ms,血钾3.4 mmol/L,给予补钾治疗;第13天,患者QTc间期561 ms,血钾3.2 mmol/L.不排除环丙沙星致QT间期延长.停用该药.6 d后患者QTc间期460 ms,血钾3.9 mmol/L.A 70-year-old female patient with motor neuron disease was given an IV infusion of ciprofloxacin 0.4 g once daily because of acute exacerbation of chronic bronchitis. On day 10,she developed hypokalemia（blood potassium 2.7 mmol/L）and potassium supplement was given. On day 11,the patient experienced loss of consciousness and cardiac arrest. The patient was given chest compression instantly and regained consciousness in three minutes. Electrocardiogram showed torsades de pointes ventricular tachycardia. Her QT corrected by heart rate（QTc）was 546 ms and blood potassium was 3.4 mmol/L.Potassium supplement was given again. On day 13,the patient′s QTc was 561 ms and blood potassium was 3.2 mmol/L. Ciprofloxacin induced QT interval prolongation was considered. On day 6 of ciprofloxacin withdrawal,the patient′s QTc was 460 ms and blood potassium was 3.9 mmol/L.

关 键 词：环丙沙星 心脏停搏 扭转性室速 

分 类 号：R541.7[医药卫生—心血管疾病] R744.8[医药卫生—内科学]