重组人白细胞介素11致双眼结膜充血和双下肢水肿  

Biliteral conjunctival hyperemia and lower extremity edema caused by recombinant human interleukin-11

作　　者：徐志英[1] 许晓东[1] 

机构地区：[1]江苏省张家港市第一人民医院药学部,215600

出　　处：《药物不良反应杂志》2017年第5期397-398,共2页Adverse Drug Reactions Journal

摘　　要：1例68岁男性结肠癌患者行卡培他滨联合奥沙利铂化疗后,因出现血小板减少,予IL-111.5 mg皮下注射、1次/d.4 d后患者出现双眼结膜充血和颜面部、双下肢水肿.停用IL-11后1 d,患者上述症状减轻.隔日再次予IL-11治疗后上述症状加重.再次停用IL-11,1 d后患者结膜充血、颜面部水肿基本消失,双下肢水肿缓解.A 68-year-old male patient with postoperative colon cancer received recombinant human interleukin-11 1.5 mg once daily by subcutaneous injection for platelet reduction after chemotherapy with capecitabine and oxaliplatin. Four days later,the patient developed bilateral conjunctival hyperemia,facial and lower limbs edema. Interleukin-11 was stopped. The symptoms gradually alleviated 1 day later. The above-mentioned symptoms aggravated at re-injection of interleukin-11 the next day. Interleukin-11 was stopped again. One day later,the patient′s conjunctival hyperemia,facial edema disappeared and lower limbs edema was improved.

关 键 词：白细胞介素类 水肿 

分 类 号：R979.5[医药卫生—药品]