生脉散防治精神神经疾病的临床和实验研究  

Clinical and Experimental Study on Prevention and Treatment of Neuropsychiatric Diseases with Shengmai Powder

作　　者：谢天 谢鸣 

机构地区：[1]北京中医药大学中医学院,北京100029

出　　处：《中国药师》2017年第10期1781-1787,共7页China Pharmacist

摘　　要：生脉散是中医补益气阴的著名方剂,具有强心复脉的功用,现代临床大多用于心血管系统疾病的防治且疗效确切。基于中医"心主神"理论,本方间或用于现代神经精神系统的疾病,但相关报道散见,有待系统整理及评估。本文在对新近20多年来相关文献搜集及筛选的基础上,从临床运用和实验药理两方面,就该方用于防治神经精神疾病方面的研究内容进行整理分析,以为临床该方拓展运用提供参考。研究发现,本方临床单用或加味或与西药合用,治疗抑郁症、抗精神病药物不良反应、脑血管意外、老年性痴呆、小儿多动症、突发性耳聋、周围神经病变、神经功能紊乱等病,具有一定疗效。实验结果表明,本方有抗应激损伤、降脂、改善血液流变性、改善脑功能等作用,为其防治神经精神系统疾病提供了一定的药理学依据。Shengmai powder, as the most famous decoration of invigorating qi and Yin in Chinese Medicine, has the function of cardiac effects and restoring pulse. It is mainly used to prevent and treat cardiovascular disease in the clinic, and has obvious curative effect. Shengmai powder, could applied in diseases of the neuropsychiatric system as the same, according to the TCM basic theory which is＆quot;heart has the function of controlling spirit, consciousness and thinking＆quot;, while few researches can be found sporadically. The related literature during late 20 years were collected, selected, combed and commented from two aspects of clinical application and ex-perimental pharmacology in order to offer a reference for expanding application of Shengmai powder in neuropsychiatric disease as while. The clinical reports indicated that Shengmai powder, its modified formulas or combination with western-medicine may have effects on many neuropsychic diseases, such as major depressive disorder（ MDD） , cerebral apoplexy, Alzheimer disease（ AD） , hyperkinetic syndrome of childhood , sudden deafness（ SD） , peripheral nerve disease（ PN） , neurological dysfunction and so on. It may also reduce toxic and side effects of antipsychotics. Pharmacology experiments results showed that Shengmai powder has lots of functions, for in-stance, Anti-psychology stress, lipid-decreasing, and improving blood rheology and cerebral functions. It provides pharmacological ref-erence on the prevention and treatment in neuropsychic disease applied by Shengmai powder.

关 键 词：生脉散 精神神经疾病 临床 实验 

分 类 号：R289.5[医药卫生—方剂学]