白细胞介素-26在感染性疾病中的研究进展  

Advances of interleukin-26 in infectious diseases

作　　者：孙珍花 吴超[1] 

机构地区：[1]南京医科大学鼓楼临床医学院感染科,南京市210008

出　　处：《中华实验和临床感染病杂志（电子版）》2017年第2期121-124,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：国家自然科学基金(No.81470093);江苏省临床医学科技专项(No.BL2012034);江苏省医学领军人才与创新团队资助项目(No.LJ201154)

摘　　要：白细胞介素(IL)-26是IL-10家族成员之一,最早由Knappe等在松鼠猴属疱疹病毒转染的T淋巴细胞中发现,并广泛存在于除鼠类以外的脊椎动物中。其主要由活化的T细胞、自然杀伤(NK)细胞以及巨噬细胞表达。IL-26的基因序列位于12q15,在干扰素(IFN)-γ和IL-22的基因之间。IL-26受体是由两种Ⅱ类细胞因子受体即IL-20受体1和IL-10受体2组成的异源二聚体受体复合物。近年来,IL-26的生物学功能有了较为深入的研究,其在银屑病、炎症性肠病、系统性硬化及类风湿关节炎等疾病的发生、发展中起到了重要的作用,且与疾病的严重程度有关。而在感染性疾病中,IL-26不仅起到促炎作用,还可能发挥着促进病原体清除与维持病原体持续感染的双重作用。本文就其在感染性疾病中的研究进展进行综述。Interleukin （IL）-26, a member of the IL-10 cytokine family, was first discovered by Knappe from herpesvirus saimiri-transformed T lymphocytes. IL-26 is widely found in vertebrates except for mice. Activated T cells, natural killer cells and macrophages are the main sources of IL-26. IL-26 is located on chromosome 12q15 between the genes for other two important cytokines, interferon （IFN）-γ and IL-22. IL-26 receptor is a heterodimeric receptor complex which is composed of two class Ⅱ cytokine receptors, IL-20 receptor 1 and IL-10 receptor 2. In recent years, the biological functions of IL-26 have been extensively studied. IL-26 was found to play an important role in the development of psoriasis, infammatory bowel diseases, systemic sclerosis and rheumatoid arthritis, and associated with the severity of the diseases. In infectious diseases, IL-26 plays a proinflammatory role and may participate in promoting pathogensclearance or maintaining persistent infection of pathogens. This review will focus on the advances of IL-26 in infectious diseases.

关 键 词：白细胞介素-26 感染性疾病 生物学功能 

分 类 号：R51[医药卫生—内科学]