基质细胞衍生因子基因多态性与冠心病相关性研究  

Study on the association between SNP of stromal cell-derived factor-1 gene and the presence of coronary heart disease

作　　者：冯磊[1] 徐文波[1] 年士艳[1] 赵阳 罗凤 叶丹[1] 张兴锋[1] 

机构地区：[1]玉溪市人民医院检验科,云南玉溪653100

出　　处：《中国优生与遗传杂志》2017年第11期10-12,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81460326)

摘　　要：目的探讨基质细胞衍生因子编码基因多态性与冠心病相关性及民族差异性。方法比较实验组和对照组间rs1801157位点等位基因和基因型频率,比较不同民族间基因型和等位基因分布情况,并与国内外已有研究结果进行比较。结果实验组与对照组间等位基因频率存在显著性差异(χ2=3.963,P=0.047<0.05),玉溪地区主要民族傣族、哈尼族、彝族、汉族(对照组)间该位点基因型和等位基因频率差异均存在显著性,汉族对照组等位基因频率还与国内外已有研究的多个民族或种族间差异存在显著性。结论基质细胞衍生因子编码基因rs1801157位点G等位基因可能为玉溪地区汉族人群冠心病的独立危险因素,该基因位点单核苷酸多态性存在民族或种族差异性。Objective：To explore the relationship between genetic variants of stromal cell-derived factor-1 rs1801157 with Coronary Heart Disease and the difference of races. Methods：To compare the Genotypes and alleles frequency between tests and controls,different races and existent results in rs1801157. Results：The G allele frequency in CHD patients was significantly higher than that in controls（P value = 0.047）. Significant differences of genotype and allele distributions in local ethnic Han（control）,Yi,Hani and Dai were observed. The geontype and allele distribution in Yuxi Han showed significant difference comparing with foreign researches with different races. Conclusion：The rs1801157 G Alleles is an independent risk factor of CHD in our population,the gene locus has the ethnic and racial differences.

关 键 词：基质细胞衍生因子 冠心病 单核苷酸多态性 

分 类 号：R541.4[医药卫生—心血管疾病]