药物治疗对妊娠期甲状腺自身抗体阴性的亚临床甲减孕妇的母儿预后影响  

The value of levothyroxine treatment in improving pregnancy outcomes in subclinical hypothyroidism women with negative thyroid antibodies

作　　者：王春芳[1] 周琼洁[1] 徐焕[1] 程海东[1] 李笑天[1] 

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中国优生与遗传杂志》2017年第11期79-81,85,共4页Chinese Journal of Birth Health & Heredity

基　　金：上海市优秀学科带头人计划(12XD1401300);上海市领军人才队伍建设和上海市公共卫生重点学科建设计划(12GWZX0301)

摘　　要：目的了解药物治疗妊娠期甲状腺自身抗体阴性的亚临床甲减孕妇是否对母儿短期预后产生影响。方法选择从2011年8月-2013年10月复旦大学附属妇产科医院孕20周内筛查出的甲状腺自身抗体阴性的亚临床甲减单胎孕妇作为研究对象,根据药物治疗情况分为治疗组和未治疗组。研究期内治疗组有184例入组,未治疗组有179例入组。结果未治疗组有4例优生引产、1例自然流产。治疗组无流产和优生引产。两组孕妇妊娠结局如妊娠期糖尿病、妊娠期高血压疾病、胎盘早剥、前置胎盘、胎膜早破、胎窘、早产、低出生体重儿、巨大儿方面的组间差异无统计学意义。结论药物治疗妊娠期自身抗体阴性的亚临床甲减不具有改善母儿短期预后的价值。Objective：The objective of study was to evaluate values of levothyroxine treatment in subclinical hypothyroidism women with negative thyroid antibodies on pregnancy outcomes.Methods：Between Aug 2011 and Oct 2013,262 subclinical hypothyroidism women screening in the first 20 gestational weeks of pregnancy with negative thyroid antibodies were recruited.184 women accepted levothyroxine treatment（intervention group）,while 179 women choosed no drug treatment（no-intervention group）.There were 1 cases with spontaneous abortion and 4 cases with artificial abortion because of fetal anomaly in the nointervention group. Results：There were no significant differences in pregnancy complications such as gestational diabetes mellitus,hypertensive disorders complicating pregnancy,placental abruption,palcenta previa,premature rupture of membrane,fetal distress,preterm birth,low birth weight,macrosomia. Conclusions：The were no intervention values of Levothyroxine treatment in improving short time pregnancy outcomes in subclinical hypothyroidism women with negative thyroid antibodies.

关 键 词：亚临床甲减 药物治疗 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]