梅毒实验诊断程序研究进展  

Research progress of laboratory detective algorithms for syphilis

作　　者：童曼莉[1] 刘莉莉[1] 林丽蓉[1] 张惠林[1] 杨天赐[1] 

机构地区：[1]厦门大学附属中山医院检验科、厦门大学医学院传染病研究所,361004

出　　处：《中华检验医学杂志》2017年第11期898-903,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金（81271335,81471967,81471231,81401749,81672094）;福建省卫生系统中青年骨干人才培养项目（2014-ZQN-ZD-34,2013-ZQN-ZD-35）

摘　　要：梅毒螺旋体不能体外培养,血清学检查依旧是梅毒实验诊断和疗效监测的主要方法.然而,单一种的血清学试验存在着敏感性或特异性的局限.由2种或2种以上梅毒血清学试验组合而成的实验诊断程序,有助于提高梅毒实验诊断效能,减少漏诊和误诊.本文阐述梅毒病原学检查、血清学试验,以及实验诊断程序等领域的研究进展,重点介绍目前存在的3种实验诊断程序的优缺点,探讨适合的梅毒感染指标的筛查方法,为有关行政主管部门制定梅毒相关法规、规范和诊疗指南提供学术参考.Syphilis can not be cultured in vitro.So far, serologic testing is still regarded as the mainstay for diagnosing syphilis and for monitoring the efficacy of subsequent antibiotic treatment.However, single serological tests have limitations in sensitivity or specificity.Detective algorithms with two or more serological methods will help to improve the effectiveness of syphilis diagnosis, and decrease missed diagnosis and misdiagnosis.This article will review advances on etiological examination, serological tests, and detective algorithms for syphilis.In particular, it specially introduces the merits and demerits of three detective algorithms for syphilis,so as to explore suitable screening methods,and provide basis for relevant administrative departments to formulate related laws, regulations and guidelines for syphilis.

关 键 词：梅毒 非特异性抗体检测 特异性抗体检测 传统的实验诊断程序 逆序实验诊断程序 

分 类 号：R446.6[医药卫生—诊断学] R759.1[医药卫生—临床医学]