机构地区:[1]攀钢集团总医院整形烧伤科,四川攀枝花617023
出 处:《中国美容医学》2017年第11期29-33,共5页Chinese Journal of Aesthetic Medicine
摘 要:目的:对比脱细胞猪皮与异体皮作为覆盖物在大面积烧伤患者自体微粒皮移植中的应用效果。方法:54例大面积深度烧伤患者以数字表法随机分为观察组(n=27)和对照组(n=27),观察组患者给予自体微粒皮移植及脱细胞猪皮覆盖治疗,对照组应用异体皮覆盖,对比两组患者微粒皮成活率、排斥反应、体温、外周血细胞及血清蛋白检测情况。结果:术后4周,两组自体微粒皮成活率比较差异无统计学意义(P>0.05)。两组患者术后各时间点体温均低于术前,差异具有统计学意义(P<0.05);但组间比较,差异无统计学意义(P>0.05)。术后7d、28d两组患者WBC计数、中性粒细胞百分比均低于术前,淋巴细胞计数高于术前,差异具有统计学意义(P<0.05);术后7d观察组WBC计数及中性粒细胞百分比均低于对照组,术后28d观察组中性粒细胞百分比低于对照组,差异有统计学意义(P<0.05)。术后7d、28d两组血清总蛋白、白蛋白、球蛋白水平均高于术前,差异具有统计学意义(P<0.05);观察组术后7d、28d血清总蛋白、球蛋白水平均高于对照组,差异有统计学意义(P<0.05)。观察组排斥反应相对较轻。结论:脱细胞猪皮替代异体皮用于自体微粒皮移植覆盖物在大面积深度烧伤患者救治中能够有效减轻患者全身炎症反应,排斥反应较轻,可改善患者的营养状态,同时解决了异体皮来源不足的问题,保证了患者烧伤部位的美观和功能恢复,值得推广。Objective To compare the clinical effects between acellular porcine skin and allogeneic skin as the wound covering materials in the treatment of autologous particulate skin graft in patients with extensive deep burns. Methods 54 patients with extensive deep burns were randomly divided into the observation group(n=27) and the control group(n=27), the observation group were treated with autologous particulate skin graft combined with acellular porcine skin covering, and the control group were covered with allogeneic skin. Then the survival rate of autologous skin grafts, reject reaction, body temperature,peripheral blood cells and serum proteins were contrasted between the two groups. Results There was no signifcantly difference in the survival rate of autologous skin grafts in 4 weeks after the operation between the two groups(P〉0.05). The temperature of the two groups at each time point was lower than that before operation(P〈0.05), but no signifcantly difference between the two groups(P〉0.05). WBC and percentage of neutrophils in 7d and 28d after the operation were signifcantly lower than before, lymphocyte counts was signifcantly higher than before in the two groups(P〈0.05), and WBC and percentage of neutrophils in 7d after the operation in the observation group were significantly lower than the control group(P〈0.05), percentage of neutrophils in 28d after the operation in the observation group was signifcantly lower than the control group(P〈0.05), but no signifcantly difference in lymphocyte counts between the two groups(P〉0.05). The levels of serum total protein and globulin in 7d and 28d after the operation were signifcantly higher than before in the two groups(P〈0.05), and the observation group significantly higher than the control group(P〈0.05). The reject reaction of the observation group was mild. Conclusion Acellular porcine skin as the wound covering materials in the treatment of autologous particulate skin graft can effectively reduce the sy
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...