胎儿纤维连接蛋白在早产诊断中的预测价值研究  

CLINICAL SIGNIFICANCE OF FETAL FIBRONECTIN IN PREDICTING PRETERM DELIVERY

作　　者：赵军[1] 马晓青[2] 吴海娜 张雪松 

机构地区：[1]河北省唐山市丰润区人民医院检验科,064000 [2]河北省唐山市丰润区人民医院妇产科,064000 [3]河北省唐山市丰润区人民医院B超室,064000

出　　处：《中国煤炭工业医学杂志》2017年第10期1151-1154,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生厅重点科技研究计划(编号:20150080)

摘　　要：目的评估胎儿纤维连接蛋白(fFN)水平对临床诊断孕妇发生早产的预测价值。方法选择产科门诊2016年1月—2017年1月期间先兆早产孕妇135例,分别取阴道后穹窿分泌物进行fFN定量和定性检测,阳性患者辅以超声测量宫颈长度,观察其妊娠结局;分析fFN定量与定性检测的结果相关性和临床一致性。结果平行比较二种fFN定量和定性检测产品测定135例孕妇,阳性符合率为100.00%,阴性符合率为98.9%;47例fFN阳性患者检后1周内和2周内的早产发生率均显著高于88例阴性患者(P<0.05);fFN阳性人群中,26例宫颈长度异常者(≤3cm),检后2周内早产发生率76.9%,显著高于宫颈长度正常者(>3cm,4.8%,P<0.05)。结论开展fFN检测对于高危孕产妇的早产预测具有重要意义,且具备了较好的临床实施条件。Objective To discuss the application value of the fetal fibronectin （fFN） in the prediction of pre- term delivery.Methods Totally 135 cases of pregnant women with threatened premature labor treated from January 2016 to January 2017 in author＇s hospital were selected.Two kinds of diagnostic kits were used for the quantitative and qualitative detection of fFN from the secretion of posterior vagina fornix, and then con- ducted cervical length measurement based on B ultrasound for the fFN positive cases,observed pregnancy out- comes, and analysed the quantitative and qualitative methods of the correlation and clinical diagnosis of consistency.Results Compared the quantitative and qualitative detection of fFN by 135 cases of pregnant women, the positive conformity rate was 100~ and negative conformity rate 98.9% .The premature delivery rate in a week and two weeks after detec tion between fFN positive group and negative group was significantly different （P〈0.05）.Among 47 fFN positive cases in two weeks after detection, the premature delivery rate of CL≤3cm group was higher than CL〉3cm group （P〈0.05）.Conclusion risk pregnant women and good implementation conditions

关 键 词：早产预测 胎儿纤维连接蛋白 宫颈长度 · 

分 类 号：R714.5[医药卫生—妇产科学]