槲皮素与5-氨基水杨酸协同治疗大鼠感染后肠易激综合征的疗效研究  

Efficacy of quercetin combined with 5-aminosalicylic acid in collaborative treatment of irritable bowel syndrome rats with infections

作　　者：黄泓轲[1] 罗健玮[1] 李晓婷 王婧雅 罗玉玮 董宁宁 

机构地区：[1]乐山职业技术学院药学系,四川乐山614000 [2]乐山职业技术学院护理系,四川乐山614000 [3]重钢总医院呼吸内科肿瘤科,重庆400081 [4]成都市第五人民医院门诊科,四川成都611130 [5]中航工业三六三医院重症医学科,四川成都610041

出　　处：《中华医院感染学杂志》2017年第22期5053-5056,共4页Chinese Journal of Nosocomiology

摘　　要：目的探讨槲皮素与5-氨基水杨酸对感染后肠易激综合征大鼠的协同治疗价值。方法按治疗方案不同将50只大鼠分为5组,每组10只,即正常对照组、模型对照组、5-氨基水杨酸组、槲皮素组和槲皮素+5-氨基水杨酸组,连续给药2周,比较5组大鼠的内脏痛阈值和粪便含水率,血清及结肠5-氨基水杨酸和N-乙酰-5-氨基水杨酸含量,血清二胺氧化酶(DAO)及分泌型免疫球蛋白(SIgA)水平的变化情况。结果与正常对照组相比,模型对照组内脏痛阈值(30.64±3.98)mmHg明显降低,粪便含水率(59.42±7.28)%明显提高,血清DAO水平(16.34±0.81)U/mL明显提高,SIgA水平(15.22±0.82)mg/L明显降低,差异有统计学意义(P<0.05);与模型对照组相比,5-氨基水杨酸组、槲皮素组、槲皮素+5-氨基水杨酸组内脏痛阈值(39.05±4.75)mmHg、(39.37±4.82)mmHg、(41.81±5.03)mmHg明显提高,粪便含水率(50.11±6.79)%、(49.60±6.51)%、(47.43±6.34)%明显降低,血清DAO水平(15.19±0.78)U/mL、(15.15±0.76)U/mL、(14.87±0.75)U/mL明显降低,SIgA水平(16.40±0.87)mg/L、(16.56±0.81)mg/L、(17.10±0.90)mg/L明显提高,差异有统计学意义(P<0.05);与5-氨基水杨酸组相比,槲皮素+5-氨基水杨酸组结肠5-氨基水杨酸含量(2037.62±375.40)ng/g明显增加,N-乙酰-5-氨基水杨酸含量(1898.73±350.56)ng/g明显降低,差异有统计学意义(P<0.05)。结论槲皮素与5-氨基水杨酸对于感染后肠易激综合征大鼠症状体征改善及治疗效果的提升均具有极其重要的协同治疗价值。OBJECTIVE To explore the value of quercetin combined with 5-aminosalicylic acid in collaborative treat-ment of irritable bowel syndrome rats with infections.METHODS A total of 50 rats were divided into 5 groups ac-cording to the treatment schedules,with 10 rats in each group,namely the normal control group,the model con-trol group,the 5-aminosalicylic acid group,the quercetin group and the quercetin plus 5-aminosalicylic acid group, with the successive administration 2 weeks.The visceral pain threshold,fecal moisture content and levels of serum and colon 5-aminosalicylic acid,N-acetyl-5-aminosalicylic acid,serum diamine oxidase（DAO）and secretory im-munoglobulin（SIgA）were observed and compared among the 5 groups of rats.RESULTS As compared with the normal control group,the visceral pain threshold of the model control group（30.64 ± 3.98）mmHg was signifi-cantly reduced,the fecal moisture content（59.42 ± 7.28）% was significantly increased,the serum DAO level （16.34 ± 0.81）U/mL was significantly elevated,and the SIgA level（15.22 ± 0.82）mg/L was（P〈0.05）.As compared with the model control group,the visceral pain threshold was（39.05 ± 4.75）mmHg in the 5-aminosali-cylic acid group,（39.37 ± 4.82）mmHg in the quercetin group,（41.81 ± 5.03）mmHg in the quercetin plus 5-aminosalicylic acid group,which was significantly increased;the fecal moisture content was（50.11 ± 6.79）% in the 5-aminosalicylic acid group,（49.60 ± 6.51）% in the quercetin group,（47.43 ± 6.34）% in the quercetin plus 5-aminosalicylic acid group,which was significantly reduced;the serum DAO level was（15.19 ± 0.78）U/mL in the 5-aminosalicylic acid group,（15.15 ± 0.76）U/mL in the quercetin group,（14.87 ± 0.75）U/mL in the querce-tin plus 5-aminosalicylic acid group,which was significantly reduced;the SIgA level was（16.40 ± 0.87）mg/L in the 5-aminosalicylic acid group,（16.56 ± 0.81）mg/L in the quercetin group,（17.10 ± 0.90）mg/L in the quercetin plus 5-aminosalicylic acid gr

关 键 词：感染后肠易激综合征 槲皮素 5-氨基水杨酸 

分 类 号：R45[医药卫生—治疗学]