罗库溴铵对患者胃肠术后感染的影响研究  

Effect of rocuronium on postoperative infections in patients undergoing gastrointestinal surgery

作　　者：陈露露 陈思思[1] 倪旭青[1] 张井井 田庆鑫 

机构地区：[1]温州医科大学附属第一医院麻醉科,浙江温州325000

出　　处：《中华医院感染学杂志》2017年第22期5156-5159,共4页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅医药科技计划基金资助项目(2016103)

摘　　要：目的探究罗库溴铵对患者胃肠术后感染的影响。方法选取2015年1月-2016年1月医院接受治疗的胃肠手术患者218例,按照随机数表法分为试验组与对照组,各109例,试验组麻醉中给予0.5mg/kg罗库溴铵,对照组给予0.12mg/kg苯磺顺阿曲库铵,观察两组患者治疗后的感染情况、麻醉后的肌松效果、麻醉后气管的插入条件级别、麻醉前后两组患者血流动力学改变以及麻醉效果与感染率的相关性。结果治疗后,试验组手术切口感染率为13.76%明显低于对照组感染率31.19%;试验组麻醉持续时间为(40.37±8.29)min,恢复指数为(17.01±3.26)min,起效时间为(1.42±0.45)min,对照组麻醉持续时间为(31.19±7.86)min,恢复指数为(12.28±3.04)min,起效时间为(2.64±0.58)min,两组比较差异有统计学意义(P<0.05);试验组麻醉后的肌松有效率94.50%,对照组麻醉后的肌松有效率86.24%,两组比较差异有统计学意义(P<0.05);诱导前后两组患者的血流动力学指标差异不大,平均动脉压(MAP)及心率(HR)均在正常范围内,差异无统计学意义。结论罗库溴铵有良好的肌松效果,可显著降低胃肠手术患者的感染率,是胃肠手术临床上比较理想的肌松药物。OBJECTIVE To explore the effect of rocuronium on postoperative infections in patients undergoing gas-trointestinal surgery.METHODS A total of 218 patients who received the gastrointestinal surgery from Jan 2015 to Jan 2016 were enrolled in the study and randomly divided into the observation group and the control group.The observation group was treated with 0.5mg/kg of rocuronium,while the control group was given 0.12mg/kg of benzene sulfonyl cisatracurium.The prevalence rate of infection after treatment,muscle relaxation effect after an-esthesia and tracheal insertion condition level after anesthesia were observed,and the relationship between the change of haemodynamics and anesthesia effect and the infection rate was analyzed before and after the anesthesia. RESULTS The incidence rate of surgical incision infection was 13.76% in the observation group after the treat-ment,significantly lower than 31.19% in the control group.The anesthesia duration was（40.37 ± 8.29）min in the observation group,（31.19 ± 7.86）min in the control group;the recovery index was（17.01 ± 3.26）min in the observation group,（12.28 ± 3.04）min in the control group;the onset time was（1.42 ± 0.45）min in the observa-tion group,（2.64 ± 0.58）min in the control group;there were significant differences between the two groups（P〈0.05）.The effective rate of muscle relaxation was 94.50% in the observation group after the anesthesia,86. 24% in the control group,and there was significant difference between the two groups（P〈0.05）.There were less significant differences in the haemodynamics indexes between the two groups of patients before and after the induction;the mean arterial pressure（MAP）and heart rate（HR）were both in normal range,and there was no significant difference.CONCLUSION Rocuronium can achieve remarkable effect on muscle relaxation and signifi-cantly reduce the infection rate of the patients undergoing gastrointestinal surgery,and it is an ideal drug for clini-cal treatment of muscle relaxation

关 键 词：感染 胃肠手术 罗库溴铵 血流动力学 苯磺顺阿曲库铵 肌松效果 

分 类 号：R619[医药卫生—外科学]