感染性肾结石患者血清及尿液细胞因子的变化观察  

Changes of serum and urine cytokines of patients with infectious kidney stones

作　　者：项龙波[1] 周东[1] 张会江[1] 李朋[1] 周小庆[1] 

机构地区：[1]浙江省丽水市人民医院泌尿外科,浙江丽水323000

出　　处：《中华医院感染学杂志》2017年第22期5172-5175,共4页Chinese Journal of Nosocomiology

基　　金：浙江省丽水市卫生局基金资助项目(2015lS282)

摘　　要：目的观察感染性肾结石患者血清及尿液细胞因子的变化情况。方法选取2013年9月-2015年10月医院收治的46例感染性肾结石患者为试验组,选取同期46名健康体检人员为对照组,比较两组血清及尿液细胞因子水平,并比较试验组中不同白细胞水平及肾积水情况患者血清及尿液细胞因子水平。结果试验组患者的血清及尿液IL-2水平分别为(10.31±1.56)ug/L及(4.63±0.66)ug/L,均低于对照组的(15.64±2.21)ug/L及(7.86±1.51)ug/L,而血清及尿液其他细胞因子IL-6、IL-10、EGF、IFN-γ及TNF-α水平分别为(7.84±1.14)pg/ml、(24.33±2.50)pg/ml、(763.64±45.98)pg/ml、(16.83±1.54)ug/ml、(1.94±0.22)ng/ml及(4.25±0.65)pg/ml、(11.31±1.54)pg/ml、(342.52±20.68)pg/ml、(7.97±1.18)ug/ml、(1.12±0.15)ng/ml,均高于对照组(3.40±0.52)pg/ml、(11.51±1.56)pg/ml、(410.55±32.52)pg/ml、(7.93±0.73)ug/ml、(0.88±0.12)ng/ml及(1.31±0.20)pg/ml、(5.45±0.64)pg/ml、(195.35±14.63)pg/ml、(3.87±0.52)ug/ml、(0.40±0.05)ng/ml,试验组中白细胞升高及存在肾积水患者的血清及尿液IL-2均低于白细胞未升高及无肾积水患者,血清及尿液其他细胞因子均高于白细胞未升高及无肾积水患者,以上比较差异均有统计学意义(P<0.05)。结论感染性肾结石患者血清及尿液细胞因子的变化明显,且受白细胞水平及肾积水的影响,应重视对患者上述血清及尿液指标的监测。OBJECTIVE To observe the changes of serum and urine cytokines of patients with infectious kidney stones.METHODS Totally 46 patients with infectious kidney stones who were treated in the hospital from Sep 2013 to Oct 2015 were chosen as the observation group,meanwhile,46 healthy people who received physical ex-amination were set as the control group.The levels of serum and urine cytokines were compared between the two groups of patients,and the levels of serum and urine cytokines were observed and compared among the patients with different levels of white blood cells or with different condition of hydronephrosis in the observation group. RESULTS The levels of serum and urine IL-2 of the observation group were respectively（10.31 ± 1.56）ug/L and （4.63 ± 0.66）ug/L,lower than（15.64 ± 2.21）ug/L and（7.86 ± 1.51）ug/L of the control group.The levels of other serum cytokines IL-6,IL-10,EGF,IFN-γ and TNF-αof the observation group were respectively（7.84 ± 1.14）pg/ml,（24.33 ± 2.50）pg/ml,（763.64 ± 45.98）pg/ml,（16.83 ± 1.54）ug/ml,（1.94 ± 0.22）ng/ml and （4.25 ± 0.65）pg/ml,（11.31 ± 1.54）pg/ml,（342.52 ± 20.68）pg/ml,（7.97 ± 1.18）ug/ml and（1.12 ± 0.15）ng/ml,higher than（3.40 ± 0.52）pg/ml,（11.51 ± 1.56）pg/ml,（410.55 ± 32.52）pg/ml,（7.93 ± 0.73）ug/ml,（0.88 ± 0.12）ng/ml and（1.31 ± 0.20）pg/ml,（5.45 ± 0.64）pg/ml,（195.35 ± 14.63）pg/ml,（3.87 ± 0.52）ug/ml and （0.40 ± 0.05）ng/ml of the control group.The levels of serum and urine IL-2 of the patients with elevated level of WBC and hydronephrosis were lower than those of the patients without elevated level of WBC or hydronephrosis in the observation group;however,the levels of other serum and urine cytokines of the patients with elevated level of WBC and hydronephrosis were higher than those of the patients without elevated level of WBC or hydronephrosis, and there were significant differences（P〈0.05）.CONCLUSION There are significant changes of serum and urine cytokines

关 键 词：感染性肾结石 血清 尿液 细胞因子 

分 类 号：R691.4[医药卫生—泌尿科学]