硝基苯席夫碱衍生物的合成、结构表征及其抗肿瘤活性研究  

Synthesis,characterization and in vitro anticancer activities of nitrobenzene Schiff base derivatives

作　　者：易岑兰 谢旭芹 刘贤智 王玉 袁泽利[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563099

出　　处：《遵义医学院学报》2017年第5期486-490,共5页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81360471;NO:81660575);贵州省国际合作项目(NO:[2012]7036);贵州省大学生创新项目(NO:201513653011);遵义医学院大学生创新项目(NO:[2014]2906)

摘　　要：目的寻找新结构的抗肿瘤先导化合物。方法将芳香醛与2,4-二硝基苯肼缩合制备得到4个新的硝基苯席夫碱衍生物(1-4)。并利用~1HNMR、^(13)C NMR、HR-MS、FT-IR等对其进行结构表征,化合物1经单晶XRD测试。采用MTT法对A549(人肺腺癌细胞)和HepG2(人源肝癌细胞)耐药细胞株进行体外抗肿瘤活性初步筛选。结果化合物4对A549(人肺腺癌细胞)和HepG2(人源肝癌细胞)具有中等活性。结论得到的系列硝基苯席夫碱化合物为今后的深入抗肿瘤活性研究与实践奠定了实验基础。Objective To discover novel lead compounds for antitumor researches. Methods Four Schiff base derivatives （1 -4 ） were obtained by conventional synthesis of aromatic aldehyde and 2,4 - Dinitrophenyl- hydrazine,and their structures were characterized by 1H NMR, 13C NMR, HR -MS and FT -IR spectrum. Compound 1 was further tested by single - crystal XRD techniques. Their anticaneer activities were investigated against A -549 and HeGp2 cell lines by MTI＂ assay. Results Compound 4 exhibited middle anticaneer activities on the two human cancer cells. Conclusion Four Sehiff base derivatives are synthesized, which serves as a good basis for further research of antieancer activities and practice.

关 键 词：硝基苯 席夫碱 合成 表征 抗肿瘤活性 

分 类 号：O625.4[理学—有机化学]