河北地区汉族人群KIR基因多态性研究  

Analysis Polymorphisms of KIR Ligands in Hebei Han Population

作　　者：赵佳[1] 苏蔓[1] 何路军[1] 戚海[1] 李茵[1] 胡光磊[1] 王远花[1] 钱明明[1] 李醒[1] 张蓓[1] 王振雷[1] 

机构地区：[1]河北省血液中心,石家庄050071

出　　处：《临床输血与检验》2017年第6期566-569,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的调查河北地区汉族人群杀伤细胞免疫球蛋白样受体(KIR)的基因频率分布情况。方法收集河北地区无血缘关系汉族人群血液样本288份,采用PCR-SSP法检测KIR基因型,统计基因频率。结果河北地区汉族人群中KIR框架基因2DL4、3DL2、3DL3、3DP1的基因频率均为100.00%,2DL1、2DL3、3DL1、2DS4、2DP1的频率较高,均>92.00%,而2DL2、2DS2、2DS3、2DS5的频率则较低;在河北汉族人群中共发现51种组合型,KIR组合型2DL4+3DP1+3DL2+3DL3+2DL1+2DL3+2DP1+3DL1+2DS4所占比例最大,约为43.75%。结论河北汉族人群中KIR基因频率与其他亚洲人群相似,不同于其他民族。KIR组合型2DL4+3DP1+3DL2+3DL3+2DL1+2DL3+2DP1+3DL1+2DS4所占比例最大。Objective To analyze the gene frequency of killer cell immunoglobulin-like receptor （KIR） in Hebei Hun population. Methods The blood samples of 288 unrelated Hebei Hun individuals were genotyped by PCR- SSP method and gene frequency was analyzed. Results Among the Hebei Hun population, framework gene KIR 2DL4, 3DL2, 3DL3 and 3DP1 was found in all samples, 2DL1, 2DL3, 3DL1, 2DS4, 2DP1 presented very high frequencies and genes 2DL2, 2DS2, 2DS3, 2DS5 presented low frequencies. A total of 51 KIR genotypes were identified, in which the genotype 2DL4＋3DPI＋3DL2＋3DL3＋2DLI＋2DL3＋2DPI＋3DLI＋2DS4 were predominant, with frequencies of 43.75%. Conclusion The gene frequencies of KIR in Hebei Han population were similar to other Asian countries but significant differences with other national minority. The genotype 2DL4＋3DPI＋3DL2＋3DL3＋2DLI＋2DL3＋2DPI＋3DLI＋2DS4 was predominant.

关 键 词：杀伤细胞免疫球蛋白受体 基因频率 基因多态性 

分 类 号：R457.7[医药卫生—治疗学] R392.4[医药卫生—临床医学]