孕妇中RhE抗原阴性分布特点  

The Positive RhE Antigen Frequency in Pregnant Women

作　　者：杨劲 何安华[1] 李凌波 

机构地区：[1]安徽省合肥市第二人民医院输血科,230001 [2]长春博迅生物技术有限责任公司

出　　处：《临床输血与检验》2017年第6期628-629,620,共3页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：吉林省科技厅重点科技成果转化项目(No.20150307011YY)资助

摘　　要：目的探讨RhE抗原阴性孕妇妊娠和生产次数与抗-E产生的关系。方法采用微柱凝胶法对2 012例孕妇进行RhE抗原、不规则抗体和ABO血型检测,并对不规则抗体阳性的孕妇进行谱细胞鉴定,检测抗-E。结果孕妇中RhE抗原阴性占53%;抗-E在首次妊娠与未育妊娠次数1次以上孕妇中的差异无统计学意义(P>0.05);抗-E在首次妊娠与生育1次以上孕妇中的差异有统计学意义(P<0.05);RhE抗原阴阳性孕妇在ABO血型分布的差异无统计学意义(P>0.05)。结论RhE阴性孕妇占比超过50%,抗-E产生以生育1次以上孕妇为主,在日益增多的生二胎家庭中意义重大。Objective To explore the relations between times of delivery and anti-E antibody frequencies in RhE- negative pregnancies. Methods Micro-column gel test was used to detect RhE antigens, irregular antibodies and ABO blood groups in 2012 pregnant women, and spectral cell identification was performed to detect anti-E antibodies in the samples with positive irregular antibodies. Results Fifty percent pregnant women were found to be RhE antigen-negative. No significant difference of positive rates of anti-E antibodies was noted between the women with first pregnancy and those with over one time of pregnancy （P〉0.05） . Additionally, no obvious difference of ABO blood group distribution was seen between RhE-negative and -positive pragnancies （P〉0.05） . Conclusions Over half of pregnant women present negative RhE antigen and the positive anti-E antibodies are frequently detectable in multipara women, which is significantly meaningful to the women with a second child.

关 键 词：RhE 妊娠 经产妇 

分 类 号：R457.11[医药卫生—治疗学] R714.1[医药卫生—临床医学]