三种促排卵方案对PCOS患者子宫腔内人工授精妊娠结局的影响  

作　　者：张隆英[1] 高云 

机构地区：[1]浙江省台州市中西医结合医院妇产科,317500 [2]浙江大学医学院附属妇产科医院,310002

出　　处：《浙江临床医学》2017年第12期2194-2196,共3页Zhejiang Clinical Medical Journal

摘　　要：目的比较3种促排卵方案对PCOS患者夫精子宫腔内人工授精妊娠结局的影响。方法收集2014年1月至2015年6月行夫精子宫腔内人工授精助孕的320对PCOS不孕夫妇452周期的临床资料，根据促排卵方案不同分为三组，分别为来曲唑组、促性腺激素（HMG）组、来曲唑联合HMG组。B超监测卵泡和子宫内膜变化并比较三组的妊娠结局。结果优势卵泡直径≥14mm的个数，HMG组最高，来曲唑联合HMG组居中，来曲唑组最低（P〈0．05）；达人绒毛膜促性腺激素（HCG）日子宫内膜厚度来曲唑组明显小于HMG组（最厚）和来曲唑联合HMG组，差异有统计学意义（P〈0．05）；来曲唑联合HMG组临床妊娠率为29％（54／187），均明显高于HMG组20％（32／162）和来曲唑组10％（10／103）。三组I晦床妊娠率差异有统计学意义（P〈0．05）。结论来曲唑联合HMG用药促排卵方案可明显提高PCOS患者子宫腔内人工授精的临床妊娠率。Objective To compare the influence of 3 ovulation induction schemes in PCOS patients who received uterine cavity artificial intrauterine insemination pregnancy. Methods A retrospective study was done with 320 PCOS infertility couples who received uterine cavity artificial insemination pregnancy of 452 cycles in woman＇s hospital school of medicine Zhejiang university from January 2014 to June 2015.According to different ovarian stimulation protocols, patients were divided into 3 groups （ LE group, HMG group and LE＋HMG group ） , and the follicle and endomentrium changes were monitored by B ultrasound and the 3 groups of pregnancy outcomes were compared. Results LE＋HMG group＇s clinical pregnancy rate was 29% （ 54/187 ） , and obvious higher than HMG group＇s 20% （ 32/162 ） and LE group＇s 10% （ 10/103 ） . The three groups of patients of comparative difference was statistically significant （ P〈0.05 ） . Conclusion The scheme of LE＋HMG can obviously improve the PCOS patients with uterine cavity artificial insemination pregnancy rate of artificial insemination.

关 键 词：PCOS促排卵子宫腔内人工授精 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]