1例利奈唑胺与磺胺类药物合用导致严重血小板减少的病例分析  

Analysis of thrombocytopenia induced by combined use of linezolid with sulfas in one patient

作　　者：屈静晗 解染 向倩[1] 马凌悦[1] 周颖[1,2] 崔一民[1,2] 

机构地区：[1]北京大学第一医院药剂科,北京100034 [2]北京大学药学院药事管理与临床药学系,北京100191

出　　处：《临床药物治疗杂志》2017年第7期76-79,共4页Clinical Medication Journal

摘　　要：目的 :关注利奈唑胺和磺胺类药物合用导致血小板减少的不良反应及处理方法。方法:通过回顾性分析1例临床病例资料,探讨不良反应发生的原因,从而提出临床工作中的药学监护事项。结果:根据不良反应关联性评价,该患者出现的严重血小板减少很可能与利奈唑胺、磺胺类药物的合用有关,其发病机制仍有争议,需要进一步的研究证实。结论:在可能导致严重不良反应发生的药物使用过程中,临床药师应当加强药学监护,警惕药物不良反应的发生,提高早期防范的意识,解决临床实际问题。Objective： To discuss the thrombocytopenia induced by combined use of linezolid with sulfas and the resolutions. Methods： The causes of the adverse reaction were investigated by retrospectively analyzing a case of pulmonary infection, in order to put forward the matters of pharmaceutical care in clinic. Results： According to the adverse reaction correlation evaluation, serious thrombocytopenia in this patient may be related with combined use of linezolid with sulfas. The mechanism of thrombocytopenia is still controversial and needs further study to confirm. Conclusion： Pharmacists should strengthen pharmaceutical care for patients receiving drugs which may cause serious adverse reactions and be alert to their occurrence, aiming at prevention of adverse reactions in early stage and make efforts to solve clinical problems.

关 键 词：利奈唑胺 磺胺类 血小板减少 药物不良反应 

分 类 号：R956[医药卫生—药学]