肠道病毒71型流行病学及其感染致中枢神经系统损伤的研究进展  

Recent advance in epidemiology of enterovirus 71 and pathogenesis of central nervous system damage induced by enterovirus 71 infection

作　　者：李帮涛 李虹艾 崔兰[3] 海元平 黄婷[1] 向伟[1] 

机构地区：[1]海南省妇幼保健院(海南省儿童医院)重症医学科,海口570206 [2]南华大学附属海南医院儿内科,海口570206 [3]海南医学院附属医院儿内科,海口570206

出　　处：《中华实用儿科临床杂志》2017年第22期1754-1756,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：海南省卫生计生行业科研项目（琼卫2012ZD-03）

摘　　要：肠道病毒71型（EV71）高度噬神经性，是引起重症手足口病及中枢神经系统（CNS）疾病重要的神经毒性病原。EV71在亚太地区广泛流行，Ev71致CNS损伤主要包括无菌性脑膜炎、脑炎、脑干脑炎、急性弛缓性麻痹等，预后差、病死率高，但损伤机制尚不明确。现就EV71相关病原学、流行病学、感染致CNS损伤的发病机制及EV71疫苗研究进展作一综述，以期为EV71相关研究提供理论依据。Enterovirus 71 （EVT1） has a high degree of nerve absorption and which is an important neurotoxic pathogen causing severe hand, foot and mouth disease and central nervous system （CNS） diseases. EV71 infection is at a high incidence in Asia Pacific region. The CNS damage caused by EV71 mainly includes aseptic meningitis, ence- phalitis, brain stem encephalitis, acute flaccid paralysis, etc, which has a high mortality and poor prognosis, while its in- jury mechanism is not clear. Now, EV71 related etiology, epidemiology, pathogenesis of CNS damage caused by EV71 infection and EVT1 vaccine research progress were summarized,in order to provide theoretical basis for EV71 related

关 键 词：肠道病毒71型 流行病学 中枢神经系统 发病机制 

分 类 号：R725.1[医药卫生—儿科]