早期流产后怀孕间隔时间的评估  

Evaluation of interpregnancy interval after early abortion

作　　者：韩仁栋 陈金虹 

机构地区：[1]同济大学附属第一妇婴保健院妇科,上海200120

出　　处：《中国妇幼保健》2017年第22期5698-5702,共5页Maternal and Child Health Care of China

摘　　要：目的分析早期流产后再次怀孕间隔时间对受孕能力的影响。方法以同济大学附属第一妇婴保健院2014年1月-2016年1月1 083例有早期流产经历的妇女为研究对象,跟进至少6个月经周期,直至怀孕并分娩。以自早期流产至开始备孕的日期为间隔时间,以备孕的时间直至怀孕为备孕时间。建立Cox离散模型,计算左截断右删失数据,在调整年龄、体质量指数、教育和不孕情况之后,评估受孕几率比(ORs)。结果间隔时间0~3个月(765例,76.7%)比间隔3个月以上(233例,23.4%)的夫妇活胎率更高(53.2%vs.36.1%,P<0.05),缩短怀孕时间5个周期可以明显提高活产率,调整后的生殖能力受孕几率是原来的1.71倍[95%CI1.30~2.25]。结论没有生理学方面的证据表明早期流产后有必要推迟再次怀孕时间。Objective To analyze the effect of interpregnancy interval after early abortion on fertilization ability.Methods A total of1 083 women with early miscarriage history were selected from the hospital from January 2014 to January 2016,then they were followed up at least 6 menstrual cycles till pregnancy and delivery.The time from early abortion to the beginning of preparing for pregnancy was interpregnancy interval,the time from preparing for pregnancy to conception was pregnancy preparation time.Cox discrete model was established,left truncation and right censored data was calculated,after adjusting age,body mass index,education,and infertility,fertilization odds ratios（ORs） were estimated.Results The live fetus rate of women（765 cases,76.7%） with 0-3 months＇ interpregnancy interval was 53.2%,which was statistically significantly higher than that of women（233 cases,23.4%） with more than 3 months ＇ interpregnancy interval（36.1%）（P〈0.05）.Shortening pregnancy time by 5 cycles can significantly improve live fetus rate,and the reproductive rate after adjustment was 0.71 times more than that before adjustment（95%CI：1.30-2.25）.Conclusion There is no physiological evidence showing the necessity to delay pregnancy after an early abortion.

关 键 词：早期流产 时间间隔 受孕能力 

分 类 号：R714[医药卫生—妇产科学]