巨泌乳素血症患者血清性激素和甲状腺激素水平研究  

Study of sex hormones and thyroid hormones in patients with macroprolactinemia

作　　者：李卿[1] 王书乐[1] 张志斌[1] 

机构地区：[1]无锡市中医医院中心实验室,江苏无锡214071

出　　处：《国际检验医学杂志》2017年第22期3097-3098,3101,共3页International Journal of Laboratory Medicine

基　　金：江苏省无锡市医院管理中心科研项目(YGZXM1546)

摘　　要：目的探讨巨泌乳素血症(M-PRL)在体内产生和集聚的可能机制。方法选取高泌乳素(HPRL)患者50例、MPRL患者50例和健康人群25例分别作为HPRL组、M-PRL组和对照组,采用化学发光法检测3组血清性激素和甲状腺素水平,对检测结果进行统计分析。结果 M-PRL组、HPRL组血清睾酮、性激素结合球蛋白(SHBG)水平均高于对照组,差异有统计学意义(P<0.05);M-PRL组、HPRL组血清雌二醇水平低于对照组,差异有统计学意义(P<0.05);M-PRL组血清孕酮水平低于对照组,差异有统计学意义(P<0.05);M-PRL组血清睾酮、雌二醇、促黄体生成素(LH)、促卵泡生成素(FSH)、SHBG水平和LH/FSH比值与HPRL组比较,差异无统计学意义(P>0.05)。结论 M-PRL血症患者体内可能存在一定程度的性腺激素水平异常和自身免疫状态异常。Objective To study the possible mechanism of in vivo production and congregation of macroprolactinemia（M-PRL）.Methods 50 cases of hyperprolactinemia（HPRL）,50 cases of M-PRL and 25 healthy persons were selected as the HPRL group,M-PRL group and control group respectively.The chemiluminescence method was adopted to detect the levels of serum hormones and thyroid hormones.Then the detection results were statistically analyzed.Results The levels of serum testosterone,sex hormone binding globulin（SHBG）,thyroglobulin antibody and thyroid peroxidase in the M-PRL and HPRL groups were significantly higher than those in the control group.Serum estradiol levels in the M-PRL and HPRL group were lower than those in control group,the difference was statistically significant（P0.05）.Serum Prog level of the M-PRL group was lower than that of the control group,the difference was statistically significant（P0.05）.However the levels of serum testosterone,estradiol,luteinizing hormone（LH）,follicle-stimulating hormone（FSH）and SHBG,and LH/FSH ratio had no statistical difference between the M-PRL group and HPRL group（P0.05）.Conclusion Certain degrees of sex hormones abnormality and autoimmune abnormality may exist in the patients with M-PRL.

关 键 词：巨泌乳素 高泌乳素血症 性激素 甲状腺激素 内分泌 

分 类 号：R446.6[医药卫生—诊断学] R58[医药卫生—临床医学]