HIV阳性孕妇所生子女低出生体重发生率及影响因素分析  

Incidence and risk factors for low birth weight of infants born to HIV positive women

作　　者：向艳妮 桂希恩[1] 韦焘[2] 热孜艳.斯拉夫 刘佳荣 明方钊 甘红辉[6] 程欢 吴波 梁科[1] 

机构地区：[1]武汉大学中南医院,武汉430071 [2]昆明医科大学,昆明650031 [3]新疆维吾尔自治区伊宁市妇幼保健院,新疆伊宁835000 [4]湖北省南漳县妇幼保健院,湖北襄阳441500 [5]湖北省武汉市武昌区疾病预防控制中心,武汉430000 [6]湖北省麻城市疾病预防控制中心,湖北黄冈438300 [7]湖北省崇阳县疾病预防控制中心,湖北咸宁437500 [8]湖北省大冶市疾病预防控制中心,湖北黄石435100

出　　处：《中国艾滋病性病》2017年第11期1028-1032,共5页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(81000758);中国性病艾滋病防治协会.艾伯维妇幼关爱及预防母婴传播基金(PMTCT 2017-005);武汉中青年医学骨干人才项目~~

摘　　要：目的探讨感染艾滋病病毒(HIV)的孕妇所生子女低出生体重情况及其相关影响因素,为中国HIV母婴阻断工作提供参考。方法以2003年1月至2014年12月湖北、河北、山西部分县市及新疆伊宁市发现的HIV阳性孕妇及其子女为研究对象,收集相关资料进行卡方检验及Logistic回归分析,探讨其子女低出生体重的危险因素。结果纳入研究的608名子女中,低出生体重31人(5.10%)。多因素Logistic回归分析表明,子女低出生体重的危险因素包括:阻断方案中含有蛋白酶抑制剂(PI)[比值比(OR)=4.491,95%可信区间(CI):1.336~15.093]、子女HIV阳性(OR=4.652,95%CI:1.547~13.995)。结论应尽早发现HIV阳性孕妇并进行抗反转录病毒治疗,同时应警惕PI类药物对子女出生体重的影响,做好早期预防和管理,以降低低出生体重发生率。Objective To investigate the characteristics of low birth weight infants born to human immunodeficiency virus（HIV） infected women and the associated factors to provide the reference for the prevention of HIV transmission from mother to child in China. Methods Information of HIV positive women and their infants from Hubei, Hebei, Shanxi provinces and Yining city of Xinjiang Uygur Autonomous Region were collected with a delivery date from Jan 2003 to Dec 2014. Chi-Square test and logistic regression were used to analyze the risk factors for infants＇ low birth weight. ResultsTotally, 608 infants were enrolled and 31 were low birth weight（5.10%）. Multi-factor logistic analysis showed that the risk factors of low birth weight consisted of regimen with protease inhibitor（PI）（OR 4.491, 95%CI 1.336-15.093） and infants＇ HIV infection（OR 4.652, 95%CI 1.547-13.995）. Conclusion HIV positive pregnant women should be detected and treated with antiretroviral therapy（ART） as early as possible. Attention should be paid to PI which affects infant＇s low birth weight. Early prophylactic measures and case management of HIV infected mothers should be taken to decrease the rate of low birth weight infants born to HIV positive mothers.

关 键 词：艾滋病病毒 孕妇 低出生体重 危险因素 

分 类 号：R512.91[医药卫生—内科学]