左旋甲状腺素对妊娠期亚临床甲状腺功能减退症妊娠结局影响的荟萃分析  

Effects of levothyroxine replacement therapy on adverse pregnancy outcomes in women with subclinical hypothyroidism： A meta-analysis

作　　者：严同[1] 钟晓卫[1] 李华琦[1] 傅徐泉[1] 李莎[1] 刘宜东[1] 

机构地区：[1]成都市第三人民医院内分泌科,四川成都610000

出　　处：《医药前沿》2017年第28期29-30,共2页Journal of Frontiers of Medicine

摘　　要：目的：妊娠期亚临床甲状腺功能减退症和多种妊娠不良结局有关,系统评价左旋甲状腺素替代治疗和本病妊娠不良结局的关系.方法：检索PubMed数据库中使用左旋甲状腺素治疗本病的随机对照试验或非随机同期对照试验.结果：共纳入3项非随机同期对照试验,包含678例受试者.结果显示无论TPOAb状态,左旋甲状腺素能降低本病患者妊娠丢失66%（P=0.02）和低体重儿出生80%（P=0.007）的风险,对于其他妊娠不良结局没有不良影响.结论：在不增加其他妊娠不良结局的情况下,左旋甲状腺素治疗能降低妊娠期亚临床甲状腺功能减退症患者妊娠丢失和低体重儿出生的风险.Objective Subclinical hypothyroidism （SCH） is associated with increased risk of adverse pregnancy outcomes. The objective of the present study was to systematically review the benefits of levothyroxine therapy in pregnant women with SCH.Method PubMed was searched for randomized controlled trials and non-randomized concurrent controlled trials of pregnant women with SCH that examined adverse pregnancy outcomes. Results Three studies involving 678 participants were included. Participants who received levothyroxine therapy were at lower risk for pregnancy loss （OR 0.44, P=0.02） and low birth weight offspring （OR 0.20,P=0.007） regardless of TPOAb status. Conclusion Levothyroxine therapy is associated with a decreased risk of pregnancy loss and low birth weight offspring among women with SCH regardless of TPOAb status.

关 键 词：左旋甲状腺素 亚临床甲状腺功能减退症 妊娠丢失 低体重儿 meta分析 

分 类 号：R714.256[医药卫生—妇产科学]