益心补肾养阴法治疗心肾阴虚证不稳定型心绞痛患者的疗效及对血脂、心肌酶学的影响  

Study on the Effect of Yixin Bushen Yangyin Therapy on Unstable Angina Pectoris of Coronary Heart Disease with Heart-Kidney Yin Deficiency Pattern and its Effect on Serum Lipids and Myocardial Enzymes

作　　者：张庆文 杨志瑜[2] 

机构地区：[1]厦门大学附属心血管病医院心内科,厦门361004 [2]河北医科大学第一医院心内科,石家庄050011

出　　处：《世界中医药》2017年第10期2386-2388,2392,共4页World Chinese Medicine

基　　金：福建省自然科学基金项目(2016D016)

摘　　要：目的:探讨益心补肾养阴法治疗心肾阴虚证不稳定型心绞痛患者的疗效及对血脂、心肌酶学的影响。方法:选自2015年12月至2016年12月期间河北医科大学第一医院收治的不稳定型心绞痛患者105例,按照随机表法分为观察组(54例)与对照组(51例)。对照组采用常规治疗,观察组在对照组基础上结合益心补肾养阴法治疗。2组疗程均为4周。比较2组治疗疗效,治疗前后主要症状积分、血脂指标和心肌酶学指标变化。结果:观察组治疗有效率(92.59%)高于对照组(70.59%),且差异有统计学意义(P<0.05);观察组治疗后胸痛、心悸及腰膝酸软积分低于对照组(P<0.05);观察组治疗后CK、CK-MB及cTnI水平低于对照组(P<0.05);观察组治疗后TC、TG、LDL-C水平低于对照组(P<0.05),而HDL-C水平高于对照组(P<0.05)。结论:益心补肾养阴法治疗心肾阴虚证不稳定型心绞痛疗效明显,且可改善患者血脂和心肌酶。Objective： To investigate the effect of Yixin Bushen Yangyin therapy on unstable angina pectoris of coronary heart disease with heart-kidney yin deficiency and the effect on serum lipid and myocardial enzymes. Methods： A total of 105 patients with unstable angina pectoris in the first hospital of Hebei Medical University from December 2015 to December 2016 were randomly divided into observation group（ n = 54） and control group（ n = 51）. The control group was treated with conventional therapy,while the observation group was treated with Yixin Bushen Yangyin therapy on the basis of the control group. The two groups were treated for 4 weeks. The therapeutic effects of the two groups were compared before and after treatment. The scores of main symptoms,blood lipid and myocardial enzyme were measured before and after treatment. Results： The total efficiency of the observation group（ 92. 59%） was higher than the control group（ 70. 59%）（ χ2= 8. 569,P〈0. 05）; the scores of palpitation,chest pain and limp aching low back and knees in observation group after the treatment were lower than that of the control group（ t = 21. 013,19. 874,20. 275,P〈0. 05）; CK,CK-MB and cTnI level lower than the observation group after treatment the control group（ t = 5. 958,17. 971,13. 764,P〈0. 05）; TC,TG and LDL-C levels after treatment in the observation group than in the control group（ t = 9.988,8. 834,10. 091,P〈0. 05）,while the level of HDL-C was higher than that of the control group（ t = 4. 755,P〈0. 05）.Conclusion： Yixin Bushen Yangyin therapy on unstable angina pectoris with heart-kidney yin deficiency is significantly effective,and improves serum lipid and myocardial enzymes.

关 键 词：益心补肾养阴法 心肾阴虚证 不稳定型心绞痛 疗效 血脂 心肌酶学 

分 类 号：R243[医药卫生—中医临床基础] R541[医药卫生—中医学]