结直肠癌术后患者气虚证的兼夹特点及其影响因素的研究  

Study on Characteristics of Accompanying Patterns with Qi Deficiency Pattern and Its Influencing Factors in Patients with Colorectal Cancer after Operation

作　　者：廖凌虹[1,2] 魏丞 崔欢[1] 王俊杰 吴同玉 

机构地区：[1]福建中医药大学中医学院,福州350122 [2]福建省中医健康状态辨识重点实验室,福州350122 [3]福建省肿瘤医院,福州350014

出　　处：《世界中医药》2017年第10期2509-2513,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(81302885)

摘　　要：目的:观察结直肠癌术后患者气虚证的兼夹特点及影响因素。方法:选取福建省肿瘤医院消化外科收治的结直肠癌术后气虚证患者78例,观察证素的兼夹特点,并分析性别、化疗情况、肿瘤部位、病理分期和GSTP1基因多态性对证素兼夹频率的影响情况。结果:所有患者都兼夹其他证素,兼夹频率大于10%的主要证素共有14种,频率最高的依次为阳虚、气滞和血虚。女性兼夹血虚、脾和肾的频率要高于男性;而男性兼夹热的频率要高于女性;化疗中的患者肝证素多于未化疗患者;肿瘤分期越高大肠证素兼夹比例越高,差异均有统计学意义(P<0.05)。对GSTP1遗传多态性型的分析显示兼夹脾证素的频率在A/A,A/G和G/G 3种基因型患者中依次下降,差异有统计学意义(P<0.05)。结论:结直肠癌术后气虚证患者普遍兼夹其他证素,虚实夹杂,虚多于实。性别、化疗、肿瘤分期和基因多态性对证素的兼夹都有一定影响。Objective： To investigate the characteristics and influence factors of the pattern elements accompanied with qi deficiency in the postoperative colorectal patients. Methods： A total of 78 postoperative colorectal patients with qi deficiency who were identified by using the method of differentiation of pattern elements. The characteristics of complicated pattern elements were studied and the effects of gender,chemotherapy,tumor site,TNM staging and GSTP1 genetic polymorphism were analyzed by comparing the frequency of pattern elements in different groups. Results： All the qi deficiency patients were accompanied with at least 1 other pattern element. Among 14 common pattern elements with frequency higher than 10%,yang deficiency,qi stagnation and blood deficiency ranked the first to third highest frequency pattern elements. The frequency of blood deficiency,spleen and kidney were higher in the female than in the male while the frequency of heat pattern was higher in the male than in the female. And the frequency of liver pattern increased significantly in the patients undergoing chemotherapy compared with that in the non-chemotherapy patients.The colon pattern frequency was significantly higher in the TNM IV stage patients than in the II and III stage patients. Furthermore the analysis on GSTP1 genetic polymorphisms showed the frequency of spleen reduced in turn in the patients carrying A/A,A/G and G/G genotypes. The difference was statistically significant（ P〈0. 05）. Conclusion： The postoperative colorectal cancer patients with qi deficiency were accompanied with other pattern commonly,and simultaneous occurrence of deficiency and excess patterns coexisted in body. Gender,chemotherapy,tumor staging and GSTP1 genetic polymorphisms can affect the frequency of pattern elements accompanying with qi deficiency.

关 键 词：结直肠癌 气虚证 证素兼夹 基因多态性 

分 类 号：R241.4[医药卫生—中医诊断学]