豫北地区2014～2016年9项呼吸道病原体的临床分布和流行病学特征  

Clinical distribution and epidemiological feature of nine respiratory pathogens in the northern area of Henan Province from 2014 to 2016

作　　者：周艳君[1] 王鹏[2] 李树军[3] 王向鹏 

机构地区：[1]新乡医学院第一附属医院检验科,河南卫辉453100 [2]新乡医学院第三附属医院输血科,河南新乡453003 [3]新乡医学院第一附属医院儿科重症监护治疗病房,河南卫辉453100 [4]新乡医学院检验学院,河南新乡453003

出　　处：《新乡医学院学报》2017年第11期982-986,共5页Journal of Xinxiang Medical University

基　　金：河南省自然科学基金项目(编号:162300410211)

摘　　要：目的了解豫北地区急性呼吸道感染患者9项呼吸道病原体的临床分布和流行病学特征,为临床有效防治急性呼吸道感染性疾病提供病原学参考依据。方法回顾性分析2014年12月至2016年11月临床送检的11 135例血清标本,采用间接免疫荧光法检测呼吸道病原体,分析9项呼吸道病原体的临床分布和流行病学特征。结果 9项呼吸道病原体感染病例数为2 630例,感染率为23.62%;位居前4位的呼吸道病原体分别为肺炎支原体(16.63%)、乙型流感病毒(2.41%)、副流感病毒(2.29%)、腺病毒(0.79%);男、女性患者9项呼吸道病原体感染率分别为21.60%(1 516/7 020)、27.07%(1 114/4 115)。<1岁组、1~5岁组、6~14岁组、15~30岁组、31~50岁组、>50岁组患者9项呼吸道病原体感染率分别为8.91%(330/3 702)、31.12%(1 424/4 576)、37.36%(634/1 697)、27.10%(90/332)、24.64%(69/280)、15.13%(83/548);<1岁组患者9项呼吸道病原体感染率低于其余5组(P<0.05)。春季组、夏季组、秋季组、冬季组患者9项呼吸道病原体感染率分别为24.66%(591/2 396)、23.86%(631/2 645)、31.09%(748/2 406)、17.90%(660/3 688),秋季组患者9项呼吸道病原体感染率高于其他3组(P<0.05)。2 630例感染患者中,混合感染患者253例,均为二重混合感染,混合感染率为2.27%。结论不同性别、不同年龄、不同季节呼吸道病原体的感染率是不同的;病毒是急性呼吸道感染的主要病原体;感染存在多重性,病原体呈现季节性分布,春秋季节更应加强预防感染的流行。Objective To investigate the clinical distribution and epidemiological feature of nine respiratory pathogens of acute respiratory tract infection patients in the northern area of Henan Province,in order to provide reference for clinical effective prevention and treatment of acute respiratory tract infection. Methods The clinical distribution and epidemiological feature of nine respiratory pathogens were analyzed by a retrospective review of 11 135 serum samples which were detected by indirect immunofluorescence method from December 2014 to November 2016. Results There were 2 630 cases with nine respiratory pathogens infection,the infection rate was 23. 62%. The main four respiratory pathogens were mycoplasma pneumonia（ 16. 63%）,influenza B virus（ 2. 41%）,parainfluenza virus（ 2. 29%）,adenovirus（ 0. 79%）. The nine respiratory pathogens infection rate of male and female was 21. 60%（ 1 516/7 020） and 27. 07%（ 1 114/4 115）,respectively. The nine respiratory pathogens infection rate of 1 year group,1-5 years group,6-14 years group,15-30 years group,31-50 years group and 50 years group was 8. 91%（ 330/3 702）,31. 12%（ 1 424/4 576）,37. 36%（ 634/1 697）,27. 10%（ 90/332）,24. 64%（ 69/280）,15. 13%（ 83/548）,respectively. The nine respiratory pathogens infection rate of 1 year group was lower than that of the other five groups（ P〈0. 05）. The nine respiratory pathogens infection rate of spring group,summer group,autumn group and winter group was 24. 66%（ 591/2 396） 、23. 86%（ 631/2 645） 、31. 09%（ 748/2 406） 、17. 90%（ 660/3 688）,respectively. The nine respiratory pathogens infection rate of autumn group was higher than that of the other three groups（ P〈0. 05）. There were 253 patients with polyinfection which all were amphimorphic polyinfection in the 2 630 patients with respiratory pathogens infection,the polyinfection rate was 2. 27%. Conclusions Respiratory pathogen infection rate was different because of different gender,different age and different

关 键 词：豫北地区 9项呼吸道病原体 临床分布 流行病学特征 

分 类 号：R378.41[医药卫生—病原生物学]