标准剂量和半量缓释型达必佳在体外受精-胚胎移植中治疗效果的比较  

Comparative Study of Full Dose and Half Dose of Decapeptyl in IVF

作　　者：赵晓明[1] 陈珠萍[1] 林其德[1] 

机构地区：[1]上海第二医科大学附属仁济医院生殖医学中心,上海200001

出　　处：《生殖与避孕》2002年第4期243-246,共4页Reproduction and Contraception

摘　　要：目的 :探索一种在体外受精 -胚胎移植 ( IVF-ET)超排卵方案中既能使垂体降调节又不至于过度抑制卵巢功能的达必佳有效剂量。方法 :比较 2 4位接受 IVF-ET助孕者的治疗效果 ,一组 1 4例( A组 )皮下注射半支 ( 1 .88mg)达必佳缓释型 ;一组 1 0例 ( B组 )接受缓释型达必佳标准剂量 3 .75mg/支。结果 :B组在使用促性腺激素 ( Gn)前及绒毛膜促性腺激素 ( h CG)注射日的黄体生成素( LH)水平明显低于 A组 ( 1 .1 6± 0 .45 IU/L vs 2 .3 8± 0 .79IU/L,P<0 .0 1 ;0 .84± 0 .60 IU/L vs2 .1 4± 0 .71 IU/L,P<0 .0 1 )。 Gn用量及用药时间大于 A组 ( 4 0 .9± 1 2 .7支 vs 3 0 .9± 4.2支 ,P<0 .0 5 ;1 4.2± 3 .0 d vs 1 1 .4± 1 .6d,P<0 .0 1 ) ,二组的 h CG注射日雌二醇 ( E2 )水平、获卵数、受精率、卵裂率、妊娠率均无统计学差异 ( P>0 .0 5 )。二组均无内源性 LH峰出现。结论 :半量达必佳能获得与全量达必佳相同的治疗结果、且能减少Objective:To investigate the optimal dose of Decapeptyl that used in the IVF superovulation protocol for the pituitary desensitization. Methods:Twenty four patients with tube infertility were involved in the study and divided into two groups according to the dose of Decapeptyl inject ed in midluteal phase; group A included 14 patients had a single dose of 1.88 mg Decapeptyl, group B had 10 patients injected a single dose of 3.75 mg Dec apeptyl. Results:The LH levels were 2.38±0.79 IU/L in g roup A and 1.16± 0.45 IU/L in group B before the day of gonadotropin, and we re 2.14±0.17 IU/L in group A and 0.84±0.60 IU/L in group B on the day of hCG. The LH level of group B was significantly lower than group A (P<0.01). The mean amount of gonadotropin was higher in group B (40.9±12.7 ampules) than in group A (30.9±4.2 ampules)(P<0.05). The length of simulation was significan tly increased in group B (14.2±3.0 days) compared with group A (11.4±1.6 days) (P<0.01). There was no difference between two groups in E 2 levels on the d ay of hCG, the number of oocytes retrieved, fertilization rate, cleavage rate an d pregnancy rate. No premature endogenous LH surge occurred in either group. Conclusion:Half dose of Decapeptyl used in IVF treatme nt achieved same effectiveness as full dose of Decapeptyl, resulting in reduct ion of the dose of gonadotropin, the length of stimulation and the cost of tre atment.

关 键 词：缓释型 达必佳 体外受精-胚胎移植 促性腺激素释放激素激动剂 控制性超排卵 不孕症 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]