环磷腺苷信号通路与血管重塑关系的研究进展  

Research Progress of the Association between c AMP Signalling Pathway and Vascular Remodeling

作　　者：高飞[1] 胡晓露[1] 陈康宁[1] 

机构地区：[1]重庆西南医院神经内科,重庆400038

出　　处：《中国卒中杂志》2017年第9期863-868,共6页Chinese Journal of Stroke

摘　　要：环磷腺苷(cyclic adenosine monophosphate,c AMP)信号通路作为一种重要的细胞内信息传递系统参与调节了多种生物活动。近期研究发现,c AMP通路的激活可有效抑制心脑血管疾病进程中的血管重塑,c AMP通路有望成为治疗上述疾病的新的靶目标。本文从c AMP通路抑制血管内皮炎症、内膜增生和血小板异常激活等方面阐述c AMP信号通路与血管重塑的关系。Cyclic adenosine monophosphate （cAMP） signaling pathway, as an important intracellular messenger delivery system, is related to modulation of multiple physiological processes. Recent studies found that activated cAMP signaling pathway could suppress vascular remodeling involved in cardiovascular and cerebrovascular diseases and it might be expected to become new target for treatment of these diseases. This paper is to illustrate the association between cAMP signaling pathway and vascular remodeling from the aspect that cAMP signaling pathway may suppress vascular endothelial inflammation, intimal hyperplasia and blood platelets excessive activation.

关 键 词：血管重塑 环磷酸腺苷 内皮细胞 平滑肌细胞 血小板 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]