2012～2016年梅州市无偿献血人群丙型肝炎感染状况调查分析  

Investigation and analysis of hepatitis C infection among voluntary blood donors in Meizhou during 2012-2016 years

作　　者：黄小珍 曾宾 HUANG Xiaozhen ZENG Bin(Meizhou Blood Center, Guangdong, Meizhou 514021, China)

机构地区：[1]广东省梅州市中心血站,广东梅州514021

出　　处：《中国医药科学》2017年第22期160-163,共4页China Medicine And Pharmacy

摘　　要：目的了解2012~2016年梅州市无偿献血人群的丙型肝炎感染状况,以期为保证无偿献血血源质量和安全提供借鉴和帮助。方法选择2012年1月~2016年12月期间梅州市无偿献血者共151 995人作为研究对象,收集这151 995例无偿献血者的血液标本,采用两种酶联免疫吸附试验试剂进行抗-HCV检测,对无偿献血者丙型肝炎感染在不同年份、不同性别、不同年龄、不同血型、不同职业的分布进行分析。对抗-HCV阳性血液标本进行丙氨酸氨基转移酶(ALT)检测(IFCC法),统计ALT检测不合格情况,并分析抗-HCV阳性血液标本ALT不合格在不同性别的分布情况。结果 151 995例无偿献血者的抗-HCV阳性率为0.058%,低于全国无偿献血人群HCV感染率,2013年的无偿献血者抗-HCV阳性率最低(0.045%),2015年最高(0.079%);男性人群、女性人群的抗-HCV阳性率分别为0.057%、0.060%,不同性别的抗-HCV阳性率比较差异无统计学意义(P>0.05);56~60岁的抗-HCV阳性率最高(0.089%),18~24岁最低(0.053%),不同年龄段的抗-HCV阳性率比较差异无统计学意义(P>0.05);AB型血的抗-HCV阳性率最高(0.080%),A型血的抗-HCV阳性率最低(0.041%),不同血型的抗-HCV阳性率比较差异无统计学意义(P>0.05);学生和军人的抗-HCV阳性率最高(0.131%),高于其它献血人群(P<0.05)。抗-HCV阳性血液标本中,共检出9例ALT不合格,ALT不合格率为10.227%,男性和女性抗-HCV病例中的ALT不合格率分别为10.769%、8.696%,差异无统计学意义(P>0.05)。结论 2012~2016年梅州市无偿献血人群的丙型肝炎感染低于全国平均水平,不同性别和年龄人群的感染分布较为均匀,而不同职业人群中,学生和军人的丙型肝炎感染率相对较高。Objective To investigate the status of hepatitis C infection among voluntary blood donors in Meizhou from 2012 to 2016, so as to provide reference and help for ensuring the quality and safety of blood donation by voluntary blood donation. Methods 151 995 unpaid blood donors in Meizhou from January 2012 to December 2016 was selected as the research objects. Blood samples were collected from blood donors. Two enzyme-linked immunosorbent assay reagents were used to detect anti - HCV. The distribution of hepatitis C infection among volunteers in different years, gender, age, blood type and occupation was analyzed. Alanine aminotransferase （ALT） test （IFCC） was performed on anti - HCV positive blood samples, the unqualified condition of ALT detection and its distribution situation of different gender in anti - HCV positive blood specimens were statistically analyzed. Results The positive rate of anti -HCV in 151 995 voluntary blood donors was 0.058%, which was lower than that of voluntary donors in China. The rate of anti -HCV positive in 2013 was the lowest （0.045%） in, and the highest in 2015 （0.079%）; The positive rates of anti -HCV in male and female groups were 0.057% and 0.060%, respectively. There was no statistical difference in the positive rate of anti -HCV between different genders （P 〉 0.05）; The positive rate of anti -HCV in 56-60 years old was the highest （0.089%）, the lowest in 18-24 years （0.053%）, and there was no statistical difference in the positive rate of anti -HCV among different age groups （P 〉 0.05）; The positive rate of anti -HCV was the highest in type AB blood （0.080%）, and the positive rate of anti -HCV in A type blood was the lowest （0.041%）. There was no statistical difference in the positive rate of anti -HCV among different blood groups （P 〉 0.05）; The positive rates of anti -HCV were highest among students and servicemen （0.131%）, higher than those of other blood donors （P 〈 0.05）. In the anti -HCV positive blood samples, 9 c

关 键 词：无偿献血 丙型肝炎感染 抗-HCV 

分 类 号：R512.63[医药卫生—内科学]