抗凝血酶Ⅲ、血浆蛋白C、血浆蛋白Z在子痫前期中的应用  

Applications of Antithrombin Ⅲ, plasma protein C, plasma protein Z in preeclampsia

作　　者：叶智良[1] 李相新[1] 周绮娴 杨晓明[1] 赵新[1] 

机构地区：[1]佛山市妇幼保健院,广东佛山528000

出　　处：《医学检验与临床》2017年第8期28-30,共3页Medical Laboratory Science and Clinics

摘　　要：目的：探索子痫前期孕妇凝血、 抗凝血和纤溶系统功能的改变与子痫前期发病的因果关系,探索各指标之间的相关性,寻找敏感有效的指标检测病情变化和判断严重程度.方法：选取子痫前期孕妇42例,其中早发型子痫前期组孕妇8例,晚发型子痫前期组孕妇34例.正常晚期妊娠妇女40例作对照组.测定PT、APTT、TT、FIB、D-D、ATⅢ、PC以及PZ,比较各项指标的差异及相关性.结果：①子痫前期孕妇与正常晚期妊娠妇女血浆中的PT、 抗凝血酶Ⅲ、 血浆蛋白C和血浆蛋白Z含量明显降低（P〈0.05）;TT和纤维蛋白原含量明显升高（P〈0.05）.②早发型子痫前期组孕妇与迟发型子痫前期孕妇血浆中的纤维蛋白原、 抗凝血酶Ⅲ、 血浆蛋白C和血浆蛋白Z含量明显降低（P〈0.05）.结论：除检测常规凝血指标PT、APTT、TT以及FIB、D-D外,联合检测ATⅢ、PC和PZ等的抗凝血指标有助于对子痫前期孕妇（特别是早发型子痫前期孕妇）病情检测,对降低母婴并发症、 提高分娩安全和保护母婴健康具有重要意义.Objective： To explore the causal relationship between the function changes of coagulant, anticoagulant and fibrinolytic system ofpreeclampsia women and the onset ofpreeclampsia, and to explore the correlation between the indexes, trying to find a sensitive and effective index test condition change and judge the severity. Methods： 42 cases of pre-eclampsia pregnant women were selected, including 8 in early preeclampsia, and 34 in the pre-eclampsia group. 40 cases of normal late pregnancy were in the control group. The determinations of PT, APTT, TT, FIB, D-D, AT Ⅲ, PC and PZ were conducted, compare the difference and relativity of these indicators. Results： （1） The plasma PT, antithrombin m, plasma protein C and plasma protein Z content in preeclampsia pregnant women were significantly decreased （P〈0.05） compared with normal late pregnant women ; The content of TT and fibrinogen was significantly elevated （P〈0.05） . （2） The plasma fibrinogen, antithrombin m, plasma protein C and plasma protein Z content of early-onset preeclampsia pregnant women significantly decreased （P〈0.05） compared with late onset preeclampsia pregnant women. Conclusion： In addidon to conventional coagulation indexes ofPT, APTT, TT and FIB, D - D, combined inspections of AT Ⅲ, anticoagulant index of PC and PZ is helpful to preeclampsia pregnant women （especially the early-onset preeclampsia pregnant women） condition detection, to reduce the maternal complications and improve the labor safety and protection of maternal and child health, and is of great significance.

关 键 词：子痫前期 ATⅢ 

分 类 号：R542.22[医药卫生—心血管疾病]