幽门螺杆菌感染对慢性阻塞性肺疾病大鼠气道炎症因子的影响  

Effect of Helicobacter pylori infection on airway inflammatory factors in rats with chronic obstructive pulmonary disease

作　　者：王慧敏[1] 戈改真 贺丽琼[1] 

机构地区：[1]内蒙古科技大学包头医学院第一附属医院,内蒙古包头014010

出　　处：《中国医药科学》2017年第21期31-33,共3页China Medicine And Pharmacy

摘　　要：目的观察Hp感染对COPD大鼠支气管肺泡灌洗液炎症水平的影响。方法选取健康雄性大鼠40只,随机分为对照组和COPD组,每组各20只。COPD组使用香烟造模并检测是否成功。随后分别随机选取每组50%的大鼠制造Hp感染模型,并检测感染是否成功。最后行支气管肺泡灌洗液,检测IL-6、IL-8、TNF-α、中性粒细胞百分数(%)。使用SPSS13.0统计软件进行数据分析,P<0.05为差异有统计学意义。结果感染Hp的COPD组大鼠支气管肺泡灌洗液中的IL-6、IL-8、TNF–α及中性粒细胞百分数(%)均较Hp阴性的大鼠明显升高,差异具有统计学意义(P<0.05)。而对照组大鼠Hp感染与否对支气管肺泡灌洗液中上述炎症细胞及炎症因子的影响较小,差异没有统计学意义(P>0.05)。结论 Hp和COPD有着密切联系,Hp的感染可以加重COPD的炎症反应,Hp感染在COPD发病机制中发挥着重要的协同作用,有可能会诱发COPD的急性加重,是COPD的危险因素之一。Objective To observe the effect of Hp infection on the level of inflammation in bronchoalveolar lavage fluid of COPD rats. Methods A total of 40 healthy male rats were randomly divided into control group and COPD group,with 20 rats in each group.The rats in Group COPD was modeled with cigarette smoke and tested if they were successful,and then 50% rats in each group were randomly selected to make Hp infection model. Finally,bronchoalveolar lavage fluid was used to detect IL-6,IL-8,TNF-alpha,neutrophil percentage（%）.SPSS13.0 statistical software was used for data analysis,and P 〈 0.05 was statistically significant. Results The levels of IL-6, IL-8, TNF-alphaand neutrophil percentage（%） in bronehoalveolar lavage fluid of group COPD infected with Hp were significantly higher than those of Hp negative rats,and the difference was statistically significant.The rats in control group Hp infection has little effect on bronchoalveolar lavage fluid in the inflammatory cells and inflammatory factors,there was no significant difference between. Conclusion Hp and COPD are closely related,and Hp infection can aggravate the inflammatory response of COPD,and it plays an important synergistic role in the pathogenesis of COPD,which may induce acute exacerbation of COPD,and is one of the risk factors of COPD.

关 键 词：幽门螺杆菌 慢性阻塞性肺疾病 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统]