肾病综合征患者血胆红素与血脂异常的关系研究  

Relationship between serum bilirubin and dyslipidemia in patients with nephrotic syndrome

作　　者：刘倩[1] 郭更新[1] 刘爱翔[1] 鲁华[1] 李素敏[2] 

机构地区：[1]河北省邢台市人民医院肾内科,河北邢台054001 [2]河北医科大学第二医院肾内科,河北石家庄050000

出　　处：《中国医药科学》2017年第21期195-198,共4页China Medicine And Pharmacy

摘　　要：目的通过对肾病综合征患者及健康人群的血胆红素和血脂的比较分析,探讨NS患者血胆红素与血脂异常的关系。方法受试对象分为两组:肾病综合征组(NS组)和健康对照组(H组)。禁食水10小时后,抽取两组患者空腹的静脉血,检测各组血清总胆红素(TBIL)、直接胆红素(DBIL)、总胆固醇(CHO)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、脂蛋白(a)[Lp(a)]。结果 NS组的TBIL、DBIL均显著低于H组,差异有统计学意义(P<0.01),CHO、TG、LDL-C、Lp(a)均显著高于H组,差异有统计学意义(P<0.01);相关分析方法提示:NS组的TBIL、DBIL与CHO、TG、LDL-C、Lp(a)分别呈明显负相关,差异有统计学意义(P<0.01)。结论 NS患者的TBIL、DBIL水平明显偏低,CHO、TG、LDL-C、Lp(a)水平明显偏高,且与血胆红素的高低呈负相关,推断血胆红素水平降低参与了NS患者血脂异常的发病机制。Objective To investigate the relationship between serum bilirubin and blood lipid abnormality in patients with NS,through comparative analysis of serum bilirubin and blood lipids in patients with nephrotic syndrome （NS） and healthy people. Methods Subjects were divided into 2 groups：nephrotic syndrome group （group NS） and healthy control group （group H）.After 10 hours of fasting,fasting venous blood was extracted from two groups,serum total bilirubin （TBIL）,direct bilirubin （DBIL）,total cholesterol （CHO）,triglyceride （TG）,low density lipoprotein （LDL-C）,lipoprotein （a）[Lp （a）] of personnel were detected. Results In group NS,TBIL and DBIL were significantly lower than those in group H （P 〈 0.01）,and CHO,TG,LDL-C,Lp （a） were significantly higher than those in group H （P 〈 O.O1）.Correlation analysis showed that TBIL,DBIL and CHO,TG,LDL-C,Lp（a） were negatively correlated in group NS （P 〈 0.01）. Conclusion The levels of TBIL and DBIL were significantly lower in NS patients,while the levels of CHO,TG,LDL-C and Lp（a） were obviously higher,and it was negatively correlated with serum bilirubin level.h concludes the decrease of serum bilirubin level is involved in the pathogenesis of dyslipidemia in NS patients.

关 键 词：肾病综合征 血清总胆红素 直接胆红素 血脂 

分 类 号：R692.6[医药卫生—泌尿科学]