肝素结合蛋白在急性主动脉夹层早期辅助诊断意义及对预后的影响  

Heparin Binding Protein in Early diagnosis of Acute Aortic Dissection and Adjuvant Effect on Prognosis

作　　者：史桂兰[1] 郭长青[1] 

机构地区：[1]江苏省中医院检验科,南京210029

出　　处：《航空航天医学杂志》2017年第11期1306-1307,共2页Journal of Aerospace medicine

摘　　要：目的探讨肝素结合蛋白(HBP)水平在急性主动脉夹层(AAD)患者早期辅助辅助诊断及预后评估中的意义。方法选择江苏省中医院心血管外科2012年11月至2015年3月期间入院,经过MRA、CTA、DSA或TTE检查已确诊为AAD的患者63例作为观察组;选择相同时间段入院并确诊为ACS的患者51例作为对照组。采用ELISA法测定HBP水平,对数据进行统计学分析。结果 HBP水平AAD患者观察组明显高于对照组(P<0.05),在患者观察组确诊病例中,死亡病例HBP水平远高于存活病例(P<0.05)。结论 HBP作为AAD早期筛查指标,其值阴性对排除AAD有很大价值,而HBP水平的高低对AAD的预后评估具有指导意义。Objective To investigate the effect of heparin binding protein（ HBP） levels in patients with acute aortic dissection（ AAD） for early diagnosis and prognosis evaluation in patients with auxiliary significance.Methods From November 2012 to March 2015 in Jiangsu Province Traditional Chinese Medicine Hospital and cardiovascular surgery during hospitalization,after MRA,CTA,DSA or TTE have been diagnosed with AAD in 63 cases as the observation group choose the same period of time and hospitalization; 51 cases were diagnosed as ACS patients as the control group.HBP level was determined by ELISA method.The data were analyzed.Results The levels of HBP in patients with AADThe observation group was significantly higher than the control group（ P〈0.05）,patients in the observation group confirmed cases and death cases of HBP is much higher than the level of survival（ P〈0.05）.Conclusions HBP AAD as early screening index,the negative value is of great value to the exclusion of AAD,while the level of HBP is important for AAD after the pre assessment.

关 键 词：急性主动脉夹层 肝素结合蛋白 颗粒蛋白 

分 类 号：R446[医药卫生—诊断学]