呼出气一氧化氮在老年慢阻肺稳定期、急性发作期及哮喘患者中的测定  

Determinations of fractional exhaled nitric oxide in elderly patients with stable COPD,AECOPD and asthma

作　　者：李小梅[1] 冯秀芬 张树荣[1] 郭守福 杨清霞[1] 代娇蓉 朱俊龙 

机构地区：[1]成都军区昆明总医院北教场病区综合内科,云南昆明650023 [2]云南省石林县鹿阜社区卫生服务中心内科,云南石林652200

出　　处：《云南医药》2017年第6期566-569,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的了解呼出气一氧化氮(Fe NO)在老年慢性阻塞性肺疾病(慢阻肺,COPD)稳定期、慢阻肺急性发作期(AECOPD)及哮喘发作期患者中的变化情况。方法对我院在2014年6月-2016年6月收治的154例老年慢阻肺稳定期(62例)、急性发作期(62例)及哮喘(30例)患者进行Fe NO测定,观察治疗前后Fe NO的变化情况,并与同期收治的62例非呼吸系统疾病老年患者进行比较。结果治疗前Fe NO的测定值在老年哮喘组[(56.6±14.6)ppb]>慢阻肺急性发作期组[(33.2±11.2)ppb]>慢阻肺稳定期组[(26.3±10.4)ppb]>非呼吸系统疾病组[(20.2±9.2)ppb],各组间比较差异均有统计学意义(均P<0.01)。各组自身治疗前后比较,治疗后哮喘组[(31.7±13.1)ppb]Fe NO和慢阻肺急性发作期组[(25.8±9.6)ppb]均较治疗前显著下降(均P<0.01),但仍高于非呼吸系统疾病组(均P<0.01);慢阻肺稳定期组治疗后其Fe NO[(23.9±9.4)ppb]有所下降,但与治疗前比较差异无统计学意义(P>0.05)。结论 Fe NO在老年哮喘患者中显著增高,在慢阻肺急性发作期患者中明显增高,在慢阻肺稳定期患者中轻度增高,治疗后则明显下降。Fe NO测定对老年患者气道炎症的评估具有很好的作用。Objective To investigate the changes of fractional exhaled nitric oxide(Fe NO) in elderly patients with stable chronic obstructive pulmonary disease(COPD), COPD with acute exacerbation(AECOPD) or asthma.Methods Fe NO testing were done in 62 elderly patients with stable COPD,62 cases with AECOPD and30 cases with asthma before and after treatment. Another 62 elderly patients without respiratory diseases were as control group. Results Before treatment, Fe NO in asthma group was [(56.6 ±14.6)ppb],in AECOPD group was[(33.2±11.2)ppb],in stable COPD group was [(26.3±10.4)ppb],and in control group was [(20.2±9.2)ppb].There were significant differences between the groups(P<0.01,respectively). After treatment at discharge, the Fe NO in AECOPD group[(25.8±9.6)ppb]and in asthma group[(31.7±13.1)ppb]was significantly decreased compared with the same group before treatment(P<0.01,respectively),but still significantly higher than control group(P<0.01,respectively). After treatment, Fe NO in stable COPD group [(23.9 ±9.4)ppb]was declined, but there was no significant difference compared with before treatment(P>0.05). Conclusion Fe NO is the highest in elderly patients with asthma, significantly higher in AECOPD patients, and slightly increases in stable COPD patients. It is decreased after treatment. Fe NO testing has a good effect to assess airway inflammation in elderly patients.

关 键 词：慢性阻塞性肺疾病 支气管哮喘 呼出气一氧化氮 老年 

分 类 号：R562.25[医药卫生—呼吸系统]