玉溪地区中老年男性PSA与前列腺疾病和其他疾病的相关性研究  

Association of PSA with prostate disease and other diseases in middle-aged and elderly men in Yuxi

作　　者：李应忠[1] 王健[1] 王龙[1] 业磊[1] 

机构地区：[1]玉溪市人民医院昆明医科大学第六附属医院泌尿外科,云南玉溪653100

出　　处：《云南医药》2017年第6期572-574,共3页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨前列腺特异性抗原与前列腺疾病和其他疾病的相关性。方法选取2010年10月-2016年10月,12 680例在我院行正常健康体检的男性抽血检测PSA,对PSA>4ng/m L、直肠指检(DRE)触及硬结或前列腺质硬或形态不规则/不对称、经腹部超声(TRUS)检查发现低回声区/结节或前列腺包膜不规则/形态失常视为异常发现,根据临床表现,作前列腺液检查,磁共振(MRI),或前列腺穿刺活检。结果 477例患者,经最后确诊前列腺癌76例,前列腺增生206例,无症状性前列腺炎168例(IV型),其他肿瘤组27例,前列腺癌组和前列腺炎组T-PSA和F-PSA分别与对照组比较(P<0.05)前列腺增生组T-PSA和F-PSA与对照组比较(P<0.05),前列腺癌组和前列腺炎组T-PSA和F-PSA比较(P>0.05),前列腺癌组F/T比值与对照组比较(P<0.01)。结论单凭PSA升高不能作出前列腺癌与慢性前列腺炎的鉴别,大部分慢性前列腺炎的患者PSA升高,由此,推测炎症本身是影响其血清PSA水平的最重要因素,在临床上应重视。Objective To investigate the association of prostate-specific antigen with prostate diseases and other diseases.Methods From Oct.2010 to Oct.2016, PSA was examined in 12 680 male with normal physical examination in our hospital.For PSA>4 ng/m L, digital rectal examination( DRE) touch the prostate with induration or stiffness or irregularity/asymmetry,and/or transabdominal ultrasound(TRUS) findings of hypoechoic areas/nodules or abnormal/abnormal prostatic capsule were regarded as abnormal findings.Expressed prostate secretion(EPS) examination,magnetic resonance imaging(MRI),or prostate biopsy were performed according to clinical manifestations.Results In 477 cases,76 cases were diagnosed as prostate cancer,206 cases of benign prostate hyperplasia(BPH), 168 cases of asymptomatic inflammatory prostatitis(NIH-IV), 27 cases of other tumor.In prostate cancer group and prostatitis group, T-PSA and F-PSA were compared with the control group(P <0.05).T-PSA and F-PSA were compared in BPH group with control group(P <0.05).T-PSA and F-PSA were compared in prostate cancer group and prostatitis group(P>0.05).The ratio of F/T in prostate cancer group was higher than that in control group(P<0.01).Conclusion Only elevated PSA does not make a distinction between prostate cancer and chronic prostatitis.Most patients with chronic prostatitis have elevated PSA.It is speculated that inflammation itself is the most important factor influencing serum PSA levels.We should pay more attention to it in clinic.

关 键 词：前列腺特异性抗原 前列腺增生 前列腺炎 

分 类 号：R679.33[医药卫生—外科学]