降钙素原在危重症患者中的应用价值  

Clinical significance of serum procalcitionin determination in critical patients

作　　者：陈祥慧[1] 张卫东[1] 王勤奋[1] 

机构地区：[1]吕梁市人民医院,山西吕梁033000

出　　处：《临床医药实践》2017年第12期918-921,共4页Proceeding of Clinical Medicine

摘　　要：目的:探讨危重症患者中降钙素原(PCT)的变化情况。方法:选择临床入住重症监护室患者111例,根据降钙素原水平高低分为观察组57例,对照组54例。两组性别、年龄及患病时间、程度比较,差异无统计学意义。分析观察组降钙素原水平升高患者的病因;观察两组降钙素原、急性生理及慢性健康(APACHEⅡ)评分及超敏C反应蛋白、死亡率的变化情况。通过统计学分析三者之间是否具有相关性。结果:观察组患者入院时PCT、APACHEⅡ评分、超敏C反应蛋白均明显高于对照组,两组比较差异有统计学意义(P<0.05)。PCT与APACHEⅡ评分、超敏C反应蛋白、死亡率呈正相关性(r=0.512、r=0.491、r=0.475,P=0.014、P=0.029、P=0.038)。结论:PCT浓度与疾病的严重程度有关,可作为判断病情与预后以及疗效观察的可靠指标。Objective： To investigate the changes of procalcitonin（ PCT） in critically ill patients. Methods： All 111 patients were enrolled in the intensive care unit. According to the level of calcitonin,all patients was divided into observation group（ 57 cases） and control group（ 54 cases）. There was no significant difference in gender,age and duration of disease between the two groups. To analyze the disease cause of procalcitionin heighten patients. The changes of calcitonin,APACHE Ⅱ score and high sensitivity C-reactive protein and mortality were observed. To observe correlation in the three factors by statistical processing. Results： In the observation group,the level of PCT,APACHE Ⅱ score and high sensitivity C-reactive protein were significantly higher than those in the control group when the patients admitted to hospital. The two groups were statistically significant（ P 0. 05）. There was a positive correlation in PCT level and APACHE Ⅱ score,high sensitivity C-reactive protein and mortality（ r = 0. 512、r = 0. 491、r = 0. 475,P = 0. 014、P = 0. 029、P = 0. 038）.Conclusion： PCT concentration is associated with the severity of the disease,PCT concentration can be used as a reliable indicator of disease and prognosis and efficacy observation.

关 键 词：降钙素原 危重症患者 超敏C反应蛋白 

分 类 号：R446.1[医药卫生—诊断学]