异元素掺杂碳点的制备及其在生物成像中的应用  

Preparation of Element-doped Fluorescent Carbon Dots and Their Applications in Biological Imaging

作　　者：刘慧[1] 刘梦丽 侯鹏[1] 黄承志[1,2] 

机构地区：[1]发光与实时分析化学教育部重点实验室,西南大学药学院,重庆400715 [2]西南大学化学化工学院,重庆400715

出　　处：《分析化学》2017年第12期1845-1856,共12页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21535006,21705132);中央高校基本科研业务费专项基金(No.XDJK2017C065)资助~~

摘　　要：荧光碳点具有良好的生物相容性和优良的抗光漂白能力,因此碳点在生物荧光成像方面的应用潜力受到广泛关注,但是碳点相对较低的荧光量子产率和缺乏近红外荧光发射的缺陷限制了碳点在荧光成像分析中的应用。随着异元素掺杂对碳点结构和荧光性质的改善,碳点被越来越广泛地用于生物成像。本文对近年来元素掺杂碳点的合成方法、异元素掺杂对碳点光学性质的影响和元素掺杂碳点在成像分析中的进展进行了综述,并对其应用前景进行了展望。Carbon dots have drawn a lot of attentions for their potential usage in bioimaging on the basis of their good biocompatibility and excellent anti-photobleaching ability. However,the relative low fluorescence quantum yield and lockage of near infrared fluorescence emission restrict their applications in the fluorescence imaging analysis. With the improvement of fluorescent properties through different elements doping,more and more carbon dots are used in biological imaging. In this paper,the synthesis of element-doped carbon dots,the influence by different elements doping and the development of element-doped carbon dots in imaging analysis are summarized,and the future prospect are anticipated.

关 键 词：碳点 元素掺杂 荧光成像 评述 

分 类 号：O657.3[理学—分析化学] TB383.1[理学—化学]