窄内径多孔层开管柱的制备及在液相色谱中的应用  

Preparation and Application of Porous Layer Open Tubular Capillary Columns with Narrow Bore in Liquid Chromatography

作　　者：李若男[1] 王亚楠[1] 彭曼华[1] 汪夏燕[1] 郭广生[1] 

机构地区：[1]绿色催化与分离北京市重点实验室,北京工业大学化学化工系,北京100124

出　　处：《分析化学》2017年第12期1865-1873,共9页Chinese Journal of Analytical Chemistry

基　　金：国家重大科研仪器研制项目(No.21527808);国家杰出青年科学基金项目(No.21625501)资助~~

摘　　要：近年来,微纳分离技术由于其内在的优势而受到越来越多的关注。多孔层开管柱是一种重要的微分离柱形式,与粗内径的多孔层开管柱(>25μm)相比,窄内径的多孔层开管柱具有更高的分离效率和更低的试剂消耗量。本文综述了内径≤25μm的窄内径多孔层开管毛细管柱的制备方法、与质谱检测联用技术以及在液相色谱中的应用研究进展,对其发展前景进行了展望。In recent years,micro/nano-scaled separation technique has attracted increasing attention due to its inherent advantages. The porous layer open tubular( PLOT) capillary column is an important microcolumn form. Comparied to wide-bore PLOT capillary columns( inner diameter > 25 μm),the PLOT capillary columns with a narrow inner diameter yield higher separation efficiency and lower reagent consumption. In this paper,the preparation methods for porous layer open tubular capillary columns with narrow inner diameter,less than or equal to 25 μm,are reviewed. Detection techniques combined with mass spectrometry and their applications in liquid chromatography are also disussed.

关 键 词：窄内径 多孔层开管毛细管柱 液相色谱 评述 

分 类 号：O652.6[理学—分析化学]