左甲状腺素钠、甲状腺片联合治疗甲减疗效及安全性评价  

Evaluation on the efficacy and safety of levothyroxine sodium combined with thyroid tablets in the treatment of hypothyroidism

作　　者：仇菊萍[1] 薛蓉 

机构地区：[1]宁夏固原市人民医院内分泌科,756000

出　　处：《中国社区医师》2017年第35期52-53,共2页Chinese Community Doctors

摘　　要：目的:探讨左甲状腺素钠联合甲状腺片治疗甲减的临床疗效及安全性。方法:收治甲减患者226例,随机平分两组。观察组给予左甲状腺素钠联合甲状腺片进行治疗,对照组单纯给予甲状腺片进行治疗。结果:观察组的临床治疗总有效率95.6%,比对照组的77.9%明显较高;观察组的TSH、CHOL、TC水平比对照组明显降低;观察组的FT_3、FT_4水平比对照组明显较高;观察组的不良反应发生率4.4%,比对照组的13.3%明显更低,组间差异均有统计学意义(P<0.05)。结论:左甲状腺素钠联合甲状腺片治疗甲减能够提高患者的临床治疗效果,有效改善患者的各项甲状腺激素水平,且不良反应较少,临床治疗安全性较高。Objective：To investigate the clinical efficacy and safety of levothyroxine sodium combined with thyroid tablets in the treatment of hypothyroidism.Methods：226 patients with hypothyroidism were selected.They were randomly divided into the two groups on average.The observation group was treated with levothyroxine sodium combined with thyroid tablets,while the control group was treated with thyroid tablets only.Results：The total effective rate of the observation group was 95.6%,which was significantly higher than that of the control group（77.9%）.The levels of TSH,CHOL and TC in the observation group were significantly lower than those in the control group.The levels of FT_3 and FT_4 in the observation group were significantly higher than those in the control group.The incidence of adverse reactions in the observation group was 4.4%,which was significantly lower than that in the control group（13.3%）.The differences between groups were statistically significant（P〈0.05）.Conclusion：Levothyroxine sodium combined with thyroid tablets for hypothyroidism can improve the clinical treatment effect of patients,which can effectively improve the level of thyroid hormone in patients,with less adverse reactions,and has high security in clinical treatment.

关 键 词：左甲状腺素钠 甲状腺片 甲减 

分 类 号：R581.2[医药卫生—内分泌]