Structure and Enhanced Antifungal Activity of a Divalent Cobalt（II） Complex with Hexaconazole  

作　　者：ZHOU Jinhua LI Jingjing LI Jie REN Guoyu REN Yinghui MA Haixia 

机构地区：[1]School of Chemical Engineering, Northwest University, Xi'an 710069, P. R. China

出　　处：《Chemical Research in Chinese Universities》2017年第6期864-868,共5页高等学校化学研究（英文版）

基　　金：Supported by the Provincial Key-point Natural Science Foundation of Shaanxi, China（No.2016JZ003） and the Training Pro- gram of Innovation and Entrepreneurship for Undergraduates in Northwest University, China（No. 2016225）.

摘　　要：A new CoII complex, [CoL4C12].2CH3CH2OH（L=hexaconazole）, was synthesized and characterized by means of elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction. The crystal structural analysis shows that the centrosymmetric Co2＋ is coordinated by four hexaconazole ligands and two C1 to form a distorted octahedral geometry. The complex forms 1D chains through the intermolecular hydrogen bonds interaction of O-H-… O and O--H…… C1. Furthermore, the antifungal activities of the complex against Grape anthracnose（I）, Botryosphaeria berengriana（II）, Botryosphaeria ribis（III） and Wheat gibberellic（IV） have been investigated and compared with those of the corresponding ligand. The results show that the complex has better antifungal activity than the ligand, which indicates that the coordination of the ligand and the metal enhances the antimicrobialactivity. KeywordsA new CoII complex, [CoL4C12].2CH3CH2OH（L=hexaconazole）, was synthesized and characterized by means of elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction. The crystal structural analysis shows that the centrosymmetric Co2＋ is coordinated by four hexaconazole ligands and two C1 to form a distorted octahedral geometry. The complex forms 1D chains through the intermolecular hydrogen bonds interaction of O-H-… O and O--H…… C1. Furthermore, the antifungal activities of the complex against Grape anthracnose（I）, Botryosphaeria berengriana（II）, Botryosphaeria ribis（III） and Wheat gibberellic（IV） have been investigated and compared with those of the corresponding ligand. The results show that the complex has better antifungal activity than the ligand, which indicates that the coordination of the ligand and the metal enhances the antimicrobialactivity. Keywords

关 键 词：CoII complex HEXACONAZOLE Crystal structure Antiftmgal activity 

分 类 号：O6[理学—化学]