养心草安神颗粒对大鼠长期毒性研究  

Study on Chronic Toxicity of Yangxincao Anshen Granule in Rats

作　　者：邱麒[1] 张睿卓 邱麟 林珠灿[2] 张龙 郭素华[2] 

机构地区：[1]福建卫生职业技术学院,福建福州350101 [2]福建中医药大学,福建福州350122 [3]福建省人民医院,福建福州350004

出　　处：《辽宁中医药大学学报》2017年第9期31-35,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：福建省科技厅重点项目(2014Y0053);福建省医学创新项目(2014-CX-11);福建省中医科研项目(wzze201304);福建省卫生和计划生育委员会青年科研项目(2014-1-33)

摘　　要：目的:观察养心草安神颗粒连续给药对大鼠的长期毒性反应及恢复情况,来评价长期服药的安全性,并为临床用药安全提供毒理学依据。方法:将成人临床拟用日剂量的80、40、20倍作为高、中、低剂量组,同溶媒对照组一起,对SD大鼠进行13周的给药期和2周的恢复期观察,测定大鼠的体质量、摄食饮水量、血液学指标、血液生化学指标、脏器系数及脏腑组织病理学检查。结果:给药期,各剂量组大鼠表现出活动倦怠,恢复期逐渐恢复正常;与溶媒对照组比较血液学指标、血液生化学指标和脏器系数均无统计学差异(P>0.05),脏腑组织病理切片未见药物导致毒性病理学改变。结论:长期服用养心草安神颗粒对大鼠无显著毒性反应和延迟毒性反应,临床给药量安全。Objective ： To observe the chronic toxicity of Yangxineao Anshen Granule （ YAG ） in rats for evaluating its safety and providing toxicological basis for clinical application. Methods： SD rats were randomly divided into the solvent control group and YAG low, moderate and high groups （ equaling to 80, 40 and 20 times of clinical estimated dose gavage once a day for 13 weeks ）. And then half of the rats were treated for 2 weeks with no administration. The routine examination, body weight changes, food-intake, hematological and hemato-biochemical indices, organ coefficients and pathology were observed during the dosing period and recovery phase. Results： YAG in each dosages were slow to move during the dosing period, but the abnormal changes turned gradually to normal during the recovery phase. And compared with the solvent control group, the indexes of hematological hematological and hemato-biochemical, coefficient of organs had no significant difference among dosage groups （ P〉0.05 ）. There was no obvious abnormality for the organs histopathologie examinations. Conclusion ： YAG had no obvious toxicity and the delayed toxicity in rats for long-term administration.

关 键 词：养心草安神颗粒 长期毒性 大鼠 

分 类 号：R256.23[医药卫生—中医内科学] R284[医药卫生—中医学]