基于聚类分析和Logistic回归分析的乙肝后肝硬化症状组合规律研究  

Study on the Combination of Traditional Chinese Medicine Symptoms of Hepatitis B Cirrhosis Based on Cluster Analysis and Logistic Regression Analysis

作　　者：李毅[1,2] 刘艳[1] 许永攀[1,2] 王小平[1] 寇小妮[2] 

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《辽宁中医药大学学报》2017年第9期164-167,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：咸阳市科技成果推广计划项目(2014KT-21);陕西省教育厅科学技术研究项目(2010JK510);陕西中医药大学附属医院课题(2014-35)

摘　　要：目的:探讨聚类分析和Logistic回归分析在乙肝后肝硬化中医症状组合规律研究中的应用。方法:采用自拟《乙肝后肝硬化的中医证候流行病学调查表》收集溃疡性结肠炎患者376例,并行聚类分析和Logistic回归分析。结果:聚类分析得出5类中医基本证候;Logistic回归分析提示:湿热内蕴证主症:苔黄腻、舌红、脉滑数等,次症:渴喜冷饮、烦躁易怒等;肝肾阴虚证主症:舌红少苔、脉细数、五心烦热等,次症:口燥咽干、花剥苔等;肝郁脾虚证主症:脉弦、情绪抑郁、便溏等,次症:胃脘胀痛、苔薄白等;脾虚湿盛证主症:苔白腻、头身困重、脉濡缓等,次症:脘腹胀满、口腻等;脾肾阳虚证主症:舌淡胖边齿痕、脉沉细弱、畏寒肢冷等,次症:苔白滑、尿少等。结论:聚类分析和Logistic回归分析结合的多元统计方法筛选出乙肝后肝硬化类基本中医证候的主要及次要症状,为该病中医辨证标准化研究提供了一种新的方法。Objective ： To explore the application of cluster analysis and Logistic regression analysis in the study of the combination of TCM symptoms in patients with liver cirrhosis after hepatitis B. Methods ： Using self-made ＂hepatitis B cirrhosis TCM syndrome epidemiology questionnaire＂, 376 cases of ulcerative colitis were collected and analyzed by Logistic regression and cluster analysis method. Results： Using cluster analysis, five common syndrome types were found. Tip ： The main symptoms of damp heat syndrome ： yellow and greasy fur, red tongue, slippery pulse number, endoretention of dampheat secondary symptoms ： thirst and cold drink, irritability ; the main symptoms of liver kidney Yin deficiency syndrome ： red tongue, less moss, pulse breakdown, dysphoria with smothery sensation, liver and kidney Yin deficiency symptoms ： dry mouth and throat, exfoliative fur; main symptoms of liver stagnation and spleen deficiency syndrome： pulse string, depression, loose stool, liver stagnation and spleen deficiency secondary symptoms： stomach pain, thin white fur; dampness clue to spleen deficiency main symptoms： white greasy tongue coating, heavy in the head and body, pulse moisten relief, dampness due to spleen deficiency symptoms： abdominal fullness, greasy mouth; spleen kidney Yang deficiency main symptoms： pale tongue edge teeth marks, the pulse was thin, aversion to cold, spleen kidney Yang deficiency syndrome secondary： white fur slippery, oliguria. Conclusion ： Cluster analysis and Logistic regression analysis of multivariate statistical methods combined with the screening of hepatitis B cirrhosis after primary and secondary symptoms of basic syndromes of traditional Chinese medicine, and provides a new method for the study of TCM standardization of the disease.

关 键 词：乙肝后肝硬化 LOGISTIC回归分析 聚类分析 症状学 证候 

分 类 号：R587.1[医药卫生—内分泌]