西红花苷对异丙肾上腺素所致大鼠心肌缺血保护作用研究  

Protective Effect of Crocin on Myocardial Ischemia Induced by Isoproterenol in Rats

作　　者：楚溪[1] 张园园 张一昕 王红芳 张建平 

机构地区：[1]河北医科大学第四医院,河北石家庄050011 [2]河北中医学院药学院,河北石家庄050091

出　　处：《亚太传统医药》2017年第23期25-27,共3页Asia-Pacific Traditional Medicine

基　　金：河北省中医药管理局项目(2015030)

摘　　要：目的:探讨西红花苷对异丙肾上腺素所致大鼠心肌缺血的保护作用。方法:大鼠灌胃给予西红花苷,灌胃7天后,通过腹腔注射异丙肾上腺素制备心肌缺血模型,测定血清中天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、肌酸激酶(CK)、乳酸脱氢酶(LDH)以及超氧化物歧化酶(SOD)、丙二醛(MDA)活性和含量的变化。结果:西红花苷显著降低心肌缺血大鼠血清中AST、ALT、CK、LDH的活性,升高SOD活性,降低脂质过氧化终产物MDA的含量。结论:西红花苷可通过抑制心肌细胞氧化应激反应,降低肌酸激酶和谷丙/谷草转氨酶的活性及释放,有效缓解异丙肾上腺素所致大鼠缺血性心肌损伤。Objective：To Study the protective effect of crocin on myocardial ischemia induced by isoproterenoi. Methods：Rats were administrated with crocin for 7 ds, then prepared myocardial ischemia model in the way of injecting isoproterenol. At last, the activi- ties of AST, ALT, CK, CK MB, LDH and SOD in the serum, and the level of MDA were determined. Results： Crocin significantly decreased the activities of AST, ALT, CK, LDH, and increased the activity of SOD, decreased the level of MDA. Conclusion： Crocin has protective effects on myocardial ischemia induced by isoproterenol. The effects may be related to inhibition of lipid peroxi- dation, and decreases in the activities of AST, ALT, CK, LDH.

关 键 词：西红花苷 异丙肾上腺素 心肌缺血 脂质过氧化 

分 类 号：R28[医药卫生—中药学]