慢性乙型病毒性肝炎患者抗病毒药物使用情况分析  

Analysis of antiviral regimen in outpatients with chronic hepatitis B

作　　者：贾莹[1] 李璐[1] 李晓光[1] 梁京津[1] 邓忠华[1] 林菲[1] 苏元波 张碧莹[1] 陈静[1] 王伟[1] 康永峰[1] 胥婕[1] 

机构地区：[1]北京大学第三医院感染疾病科,北京100191

出　　处：《中国临床药理学杂志》2017年第22期2308-2310,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的了解综合医院肝炎门诊慢性乙型病毒性肝炎(乙肝)患者的抗病毒药物治疗方案。方法选取2014年1月至2016年1月在肝炎门诊首次就诊的具有抗病毒治疗指征的慢性乙肝患者,用回顾性研究方法,横断面分析门诊慢性乙型肝炎患者抗病毒药物治疗方案。结果门诊慢性乙型肝炎患者约83.9%的患者正在使用抗病毒药物,其中口服核苷(酸)类药物为主,核苷(酸)类药单用或联合占78.0%,干扰素α联合核苷(酸)类药物占16.4%,干扰素α单用占5.6%。核苷(酸)类药物中使用最多的为恩替卡韦,其次是阿德福韦酯。结论目前肝炎门诊慢性乙肝患者抗病毒药物治疗方案以口服核苷(酸)类药物为主,其中恩替卡韦最常见,干扰素α的使用有待进一步提高。Objective To study the antiviral regimen among outpatients with chronic hepatitis B in general hospital.Methods Outpatients diagnosed with chronic hepatitis B between January 2014 and January 2016 were included.All of them needed antiviral therapy.Retrospective study was done to their antiviral agents with cross-section analysis.Results A total of 83.9% outpatients with chronic hepatitis B were accepting antiviral therapy and most of them used nucleos（t） ide analogs.There were78.0% of them chosed single or combined nucleos（t） ide analogs,16.4% chosed interferon α plus nucleos（t） ide analogs,5.6% chosed single interferon α.The most frequently used nucleos（t） ide analogs were Entecavir and then adefovir dipivoxil.Conclusion Nucleos（t） ide analogs were frequently used in outpatients with chronic hepatitis B and Entecavir ranked first place.Interferon α should be enhanced.

关 键 词：慢性乙型病毒性肝炎 抗病毒药物 现况调查 

分 类 号：R978.7[医药卫生—药品]