裸花紫珠正丁醇部位的化学成分研究  

N-butanol-soluble Chemical Constituents from Callicarpa nudiflora

作　　者：王杰[1,2] 付辉政 周志强 马员宇 马双成 罗跃华[2] 

机构地区：[1]南昌大学药学院,南昌330006 [2]江西省药品检验检测研究院江西省药品与医疗器械质量工程技术研究中心,南昌330046 [3]中国食品药品检定研究院,北京100050

出　　处：《中国药学杂志》2017年第22期1983-1987,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81373955);江西省自然科学基金资助项目(20142BAB205085)

摘　　要：目的研究裸花紫珠(Callicarpa nudiflora Hook.)正丁醇部位的化学成分。方法利用硅胶、ODS、Sephadex LH-20柱色谱、制备液相色谱等方法进行分离纯化,根据波谱数据分析和文献资料鉴定化合物的结构。结果从裸花紫珠正丁醇部位分离得到9个化合物,分别鉴定为:6-O-caffeoyl ajugol(1),leucosceptoslde A(2),6-O-咖啡酰-β-D-葡萄糖(3),nudifloside(4),木犀草素-7-O-葡萄糖苷(5),槲皮素3'-O-β-D-葡萄糖苷(6),cistaneside C(7),毛蕊花糖苷(8)和syringalide A 3'-α-L-rhamnopyranoside(9)。结论化合物1,2,6,7,9为首次从裸花紫珠中分离得到。OBJECTIVE To study the chemical constituents of Callicarpa nudiflora. METHODS The chemical constituents were isolated and purified by column chromatography on silica gel, ODS, Sephadex LH-20 and MPLC. Their structures were elucidated by spectroscopic evidence and compared with those in literature. RESULTS Nine compounds were isolated and identified as 6-O-caffeoyl ajugol（1）, leucosceptoslde A（2）, 6-O-caffeoly-β-glucose（3）, nudifloside（4）, luteolin-7-O-glucoside（5）, quercetin 3′-O-β-D-glucoside（6）, cistaneside C（7）, acteoside（8）, and syringalide A 3′-α-L-rhamnopyranoside （9）. CONCLUSION Compounds 1, 2, 6, 7, and 9 are isolated from this plant for the first time.

关 键 词：裸花紫珠 马鞭草科 6-O-caffeoyl ajugol leucosceptoslde A 槲皮素3'-O-β-D-葡萄糖苷 

分 类 号：R284[医药卫生—中药学]