星点设计-响应面法优选细梗香草总皂苷自微乳处方  

Optimization of Self-microemulsion Containing Total Saponins from Lysimachia capillipes by Central Composite Design-response Surface Methodology

作　　者：徐翔英 谢秋情 郑冬梅 衷林清 潘馨[1] 廖华军[1] 

机构地区：[1]福建中医药大学,福州350122

出　　处：《中国药学杂志》2017年第22期2012-2017,共6页Chinese Pharmaceutical Journal

基　　金：福建省引导性项目资助(2015Y0066)

摘　　要：目的采用星点设计-响应面法优选细梗香草总皂苷自微乳处方。方法在溶解度考察、配伍试验与三元相图绘制的基础上,以乳化时间、平均粒径及Zeta电位为评价指标,采用星点设计-响应面法筛选细梗香草总皂苷自微乳的最佳处方,并对细梗香草总皂苷自微乳的理化性质进行考察。结果细梗香草总皂苷自微乳最佳处方为油酸乙酯-Kolliphor RH40-Transcutol=12.93∶57.25∶29.82,其平均粒径、多分散指数、Zeta电位、载药量分别为23.0 nm、0.160、-20.28 mV、10.52 mg·g^(-1)。结论星点设计-响应面法所建数学模型预测性好,可用于优化细梗香草总皂苷自微乳。OBJECTIVE To optimize the formulation of self-microemulsion containing total saponins from Lysimachia capillipes by central composite design-response surface methodology. METHODS Based on the study of solubility, compatibility test and ternary phase diagram, central composite design-response surface methodology was adopted to optimize the best prescription with the emulsifying time, particle size, and Zeta pontential as indexes, physicochemical properties of this self-microemulsion were also determined. RESULTS Optimum formulation was 12.93% of ethyl oleate, 57.25% of Kolliphor RH40, 29.82% of Transcutol. The a verage particle size, polydispersity index, Zeta pontential and drug loading of self-microemulsion containing total saponins from Lysimachia capillipes were 23.0 nm,0.160,-20.28 mV and 10.52 mg·g^-1.CONCLUSION With good predictability, this METHODS can be used for the formulation optimization of self-microemulsion loaded total saponins from Lysimachia capillipes.

关 键 词：总皂苷 细梗香草 自微乳 配伍实验 三元相图 星点设计-响应面法 

分 类 号：R944[医药卫生—药剂学]