百草枯中毒机制及临床治疗进展  

Paraquat poisoning mechanism and its clinical treatment progress

作　　者：孙百胜 何跃忠[2] 

机构地区：[1]解放军第三0七医院急诊科,北京100071 [2]北京军事医学科学院科技部,100850

出　　处：《中华危重病急救医学》2017年第11期1043-1046,共4页Chinese Critical Care Medicine

基　　金：国家科技支撑计划项目（2012BA138B04）

摘　　要：百草枯（PQ）是一种具有内吸和触杀作用的快速灭生性除草剂,能高效作用于绿色植物,被广泛用于农业生产中,在我国农药市场上占有很大的比例.PQ中毒已经成为我国最常见的农药中毒之一,PQ可与土壤迅速结合而钝化,但对人毒性极大,国内外对PQ中毒尚无特效解毒药,口服PQ中毒病死率高达95%.目前临床上多采用洗胃、导泄、利尿、血液净化等综合救治措施,但治疗效果不佳,病死率居高不下.寻找PQ的特效救治措施已成为急诊医学研究的热点之一.本文对PQ中毒机制及临床治疗进展进行简要综述,为PQ的基础研究和临床救治提供新的探索方向和治疗思路.Paraquat （PQ） as a kind of sterile and herbicides, has effects of contact-kill and systemic action, which can be absorbed quickly by green plants and make them wither and die. Therefore, it is widely used in the agricultural production and occupies a large part in our country＇s pesticide market. PQ poisoning has become one of the most common pesticide poisoning in our country. PQ can be passivated when combining with soil, but it has great toxicity for human. There are still no specific antidotes for PQ poisoning at home and abroad, and the death rate of PQ oral poisoning is up to 95%. Clinically comprehensive treatment is adopted, including gastric lavage, intentional diarrhea, diuresis and blood perfusion. However, the therapeutic effect is not good and the case fatality rate keeps high. It has become one of the hot issues for emergency medicine study to search PQ＇s special efficiency measures. This paper briefly reviews PQ＇s poisoning mechanism and its clinical treatment progress to provide new exploration direction and treatment ideas for basic research and clinical treatment of PQ.

关 键 词：百草枯 中毒机制 肺损伤 治疗进展 

分 类 号：R595.4[医药卫生—内科学]