前馈控制技术研究进展及其在中药质控中的应用展望  

Research progress on feedforward control strategy and its application prospect in quality control of Chinese materia medica

作　　者：王晓宇 李文龙[1] 瞿海斌[1] 

机构地区：[1]浙江大学药学院药物信息学研究所,浙江杭州310058

出　　处：《中草药》2017年第21期4560-4564,共5页Chinese Traditional and Herbal Drugs

基　　金：国家"重大新药创制"科技重大专项(2014ZX09201022-009-001)

摘　　要：前馈控制是化工领域广泛使用的过程控制方法,主要用于减少控制目标的波动,也在化学药品生产过程质量控制中得到应用。中药生产过程的前馈控制方法是指在理解物料性质、工艺参数与产品质量之间关系的基础上,建立工艺参数优化模型,根据物料性质计算合适的工艺参数,从而减少原料质量波动对产品质量的影响。主要介绍前馈控制技术的研究进展,并展望其在中药生产领域的应用前景。As a widely applied process control strategy in chemical industry,the feedforward control strategies have been applied in pharmaceutical manufacturing to reduce the quality fluctuation of drugs.The application of feedforward control strategy in the manufacturing of Chinese materia medica（CMM） can help us to understand the relationship between input material attributes,process parameters and critical quality attributes（CQAs）,and then to establish an optimal model for the adjustment of process parameters based on input material attributes with the aim of minimizing the variation of CQAs.Before the production of the new batch,the most suitable process parameters for the input materials can be calculated by the optimal model.The motivation of this paper is to provide an overview of recent research on application of feedforward control strategies in pharmaceutical manufacturing and demonstrate perspectives of their application in CMM.

关 键 词：质量源于设计 前馈控制 实验设计 制药技术 质量控制 

分 类 号：R283[医药卫生—中药学]