肺泡呼出气一氧化氮联合25羟维生素D测定对系统性硬化症相关肺间质病变的临床价值  

Diagnostic value of CANO and 25OH-D in systemic sclerosis-associated interstitial lung diseases

作　　者：梁志强[1] 姜凤云[1] 赵蕾[1] 张勃[2] 杜丽艳[2] 张庆[2] 王雪燕[1] 庞桂芬[2] 

机构地区：[1]承德医学院附属医院风湿免疫科,河北承德067000 [2]承德医学院附属医院呼吸内科,河北承德067000

出　　处：《解放军医学院学报》2017年第11期1037-1039,共3页Academic Journal of Chinese PLA Medical School

基　　金：承德市科学技术研究与发展计划项目(201701A052)~~

摘　　要：目的研究系统性硬化症患者肺泡呼出气一氧化氮(alveolar nitric oxide concentration,CANO)及血清25羟维生素D(25OH-D)水平变化及其临床意义。方法采用酶联免疫法检测2015年6月-2016年12月就诊于本院的26例系统性硬化症合并肺间质病变患者、24例系统性硬化症未合并肺间质病变患者及50例健康对照组血清25OH-D浓度水平,同时检测受试者肺泡呼出气一氧化氮浓度,探讨两个指标在各组之间的表达差异。结果系统性硬化症合并肺间质病变组血清25OH-D水平[(23.4±4.9)nmol/L]低于未合并肺间质病变组[(30.9±4.1)nmol/L]及健康对照组[(55.6±11.3)nmol/L],差异有统计学意义(P均<0.05),系统性硬化症合并肺间质病变组CANO浓度[(11.1±4.7)mm^3/m^3]高于未合并肺间质病变组[(5.7±3.4)mm^3/m^3]及健康对照组[(2.3±1.2)mm^3/m^3](P均<0.05)。结论与健康对照组及系统性硬化症未合并肺间质病变患者相比,系统性硬化症合并肺间质病变患者25OH-D水平显著降低,CANO水平明显增高,检测血清25OH-D及CANO水平对系统性硬化症合并肺间质病变诊断有一定参考价值。Objective To study the diagnostic value of alveolar nitric oxide concentration（CANO） and 25 OH-D in systemic sclerosis-associated interstitial lung diseases. Methods From June 2015 to December 2016, 26 cases with systemic sclerosisassociated interstitial lung disease, 24 cases with systemic sclerosis without interstitial lung disease and 50 healthy controls were recruited in our hospital. Their serum 25 OH-D levels and CANO were detected and compared between 3 groups. Results The serum 25 OH-D level of systemic sclerosis-associated interstitial lung diseases patients（23.4±4.9 nmol/L） was lower than those of systemic sclerosis without interstitial lung diseases patients（30.9±4.1 nmol/L） and healthy controls（55.6±11.3 nmol/L）（P〈0.05, respectively）. CANO in patients with systemic sclerosis-associated interstitial lung disease（11.1±4.7 mm^3/m^3） was higher than those in the patients without interstitial lung disease（5.7±3.4 mm^3/m^3） and healthy controls（2.3±1.2 mm^3/m^3）（P〈0.05, respectively）. Conclusion Compared with interstitial lung disease patients and healthy controls, 25 OH-D in patients with systemic sclerosis-associated interstitial lung disease decreases significantly, and CANO increases significantly. Serum 25 OH-D and CANO are valuable for the diagnosis of systemic sclerosis-associated interstitial lung diseases.

关 键 词：系统性硬化症 25羟维生素D 肺泡呼出气一氧化氮 

分 类 号：R593.25[医药卫生—内科学]