昼夜节律产生和维持的调控系统  

Regulation system for generation and maintenance of circadian rhythms

作　　者：邢陈[1] 宋伦[1] 

机构地区：[1]军事医学科学院基础医学研究所军事应激医学研究室,北京100850

出　　处：《军事医学》2017年第8期698-702,共5页Military Medical Sciences

基　　金：全军医学科研"十二五"重大资助项目(AWS14J011);北京市自然科学基金青年资助项目(7164287);细胞应激生物学国家重点实验室(厦门大学)开放基金资助项目(SKLCSB2016KF010)

摘　　要：昼夜节律是在一系列生物钟基因(bmal1、clock、cry、per)和钟控基因(rev-erbα、rorα、dbp、tef、hlf等)的转录和翻译调控环路、翻译后修饰和降解机制的周期性驱动下,机体的生理、生化、行为等生命活动表现为以大致24 h为周期的振荡规律现象。昼夜节律产生和维持的调控系统由中枢和外周生物钟系统、节律输入系统和节律输出系统组成。节律输入系统感受并向中枢生物钟系统传递以光信号为代表的环境同步信号,中枢生物钟系统作为昼夜节律主起搏器通过输出系统将产生的节律信号传递至外周,并与外周器官内源性生物钟系统协同作用维持机体的生理活动。光照、温度、进食时间、营养物质、代谢相关因子等多种内源和外源性调控因子可作用于生物钟网络并在昼夜节律稳态维持中发挥重要作用。该文将着重阐述昼夜节律产生和维持的生理基础及相关调控因子。Circadian rhythms are driven by the transcriptional and translational oscillator and post-transcriptional modification on clock genes（ bmal1,clock,cry and per） and clock control genes（ rev-erbα,rorα,dbp,tef and hlf）,which keeps the body＇s physiologies,behavior,and other life activities and shows roughly 24-hour oscillation. The circadian clock system consists of the central and peripheral clock system,rhythm input and output system. The input system receives and transfers the light signals to the central clock system that functions as the main pacemaker to generate and output the circadian signals to the peripheral organ,which works together with the local endogenous circadian system to maintain the body＇s physiological activities. A variety of endogenous and exogenous factors,such as light,temperature,time of food intake,nutrients and metabolic related factors, play important roles in regulating the circadian clock system and maintaining homeostasis of circadian rhythms. Here,we focuses on the regulating system and related regulating factors for the generation and maintenance of circadian rhythms.

关 键 词：昼夜节律 生物钟 钟控基因 调控因子 

分 类 号：R33[医药卫生—人体生理学]